459200-50-1 Usage
Structure
Contains a benzimidazolone ring and a diethyl-dihydropyrazolyl group connected by a linker
Potential pharmaceutical applications
Due to its unique structure and the presence of the pyrazolyl group
Biological activities
The pyrazolyl group has been associated with various biological activities
Research needed
Further exploration of the pharmacological properties and potential uses in drug discovery and development.
Check Digit Verification of cas no
The CAS Registry Mumber 459200-50-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,5,9,2,0 and 0 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 459200-50:
(8*4)+(7*5)+(6*9)+(5*2)+(4*0)+(3*0)+(2*5)+(1*0)=141
141 % 10 = 1
So 459200-50-1 is a valid CAS Registry Number.
459200-50-1Relevant academic research and scientific papers
Benzimidazolone p38 inhibitors
Dombroski, Mark A.,Letavic, Michael A.,McClure, Kim F.,Barberia, John T.,Carty, Thomas J.,Cortina, Santo R.,Csiki, Csilla,Dipesa, Alan J.,Elliott, Nancy C.,Gabel, Christopher A.,Jordan, Crystal K.,Labasi, Jeff M.,Martin, William H.,Peese, Kevin M.,Stock, Ingrid A.,Svensson, Linne,Sweeney, Francis J.,Yu, Chul H.
, p. 919 - 923 (2007/10/03)
The synthesis and in vitro p38α activity of a novel series of benzimidazolone inhibitors is described. The p38α SAR is consistent with a mode of binding wherein the benzimidazolone carbonyl serves as the H-bond acceptor to Met109 of p38α in a manner analogous to the pyridine nitrogen of prototypical pyridylimidazole p38 inhibitors. Potent p38α activity comparable to that of several previously reported p38 inhibitors is observed for this novel chemotype.
