4594-52-9

Basic information

• Product Name: 1,3,5-Tri-O-acetyl-2-deoxy-D-erythro-pentofuranose
• Synonyms: 1,3,5-TRI-O-ACETYL-2-DEOXY-D-ERYTHRO-PENTOFURANOSE;1,3,5-Tri-O-acetyl-2-deoxy-D-ribose;D-erythro-Pentofuranose, 2-deoxy-, 1,3,5-triacetate;[5-acetyloxy-2-(acetyloxymethyl)oxolan-3-yl] acetate;[5-acetyloxy-2-(acetyloxymethyl)oxolan-3-yl] ethanoate;acetic acid [5-acetoxy-2-(acetoxymethyl)tetrahydrofuran-3-yl] ester;1,3,5-tri-O-acetyl-α,β-D-2-deoxyribofuranoside;1,3,5-Tri-O-acetyl-2-deoxy-D-erythro -enthropentofuranose
• CAS NO: 4594-52-9
• Molecular Formula: C₁₁H₁₆O₇
• Molecular Weight: 260.24
• Mol File: 4594-52-9.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 329.297 °C at 760 mmHg
• Flash Point: 142.967 °C
• Appearance: /
• Density: 1.241 g/cm³
• Vapor Pressure: 0.000179mmHg at 25°C
• Refractive Index: 1.466
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1,3,5-Tri-O-acetyl-2-deoxy-D-erythro-pentofuranose(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,5-Tri-O-acetyl-2-deoxy-D-erythro-pentofuranose(4594-52-9)
• EPA Substance Registry System: 1,3,5-Tri-O-acetyl-2-deoxy-D-erythro-pentofuranose(4594-52-9)

Safety Data

• Hazardous Substances Data: 4594-52-9(Hazardous Substances Data)

Usage

Uses

1,3,5-Tri-O-acetyl-2-deoxy-D-ribose is used in the chemoenzymic preparation of nucleosides.

InChI:InChI=1/C11H16O7/c1-6(12)15-5-10-9(16-7(2)13)4-11(18-10)17-8(3)14/h9-11H,4-5H2,1-3H3

Upstream product

• 452-51-7 D-2-deoxyribose 
• 108-24-7 acetic anhydride 
• 533-67-5 2-Deoxy-D-ribose 
• 51255-17-5 1-O-methyl-2-deoxy-D-ribofuranoside 
• 151767-35-0 3,5-di-O-acetyl-2-deoxy-α/β-D-ribofuranoside 
• 36792-88-8 2-deoxy-D-ribose 

Downstream Products

• 500361-29-5 1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-3-hydroxy-2-methyl-1H-pyridin-4-one 
• 500361-30-8 2,2-Dimethyl-propionic acid 1-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-methyl-4-oxo-1,4-dihydro-pyridin-3-yl ester 
• 1254186-96-3 1-(3,5-di-O-acetyl-2-deoxy-D-ribofuranosyl)-5-azacytosine 
• 22432-93-5 4-amino-1-(O³,O⁵-diacetyl-β-D-erythro-2-deoxy-pentofuranosyl)-1H-[1,3,5]triazin-2-one 
• 14599-46-3 5-carboxy-2'-deoxyuridine 
• 22432-93-5 3',5'-O-acetyl-2'-deoxy-5-azacytidine 
• 22969-05-7 1-(4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-2-one 
• 1402737-97-6 p-tolyl-3,5-di-O-acetyl-1-thio-2-deoxy-α-D-ribofuranoside 
• 1402737-50-1 p-tolyl-3,5-di-O-acetyl-1-thio-2-deoxy-β-D-ribofuranoside 
• 367518-79-4 C₅₅H₆₆N₇O₁₇PSi 
• 367518-81-8 6-[2’-deoxy-3’-O-dimethoxytrityl-α-D-ribofuranose-1’-yl]amino-5-nitro-2-(phenoxylacetyl)amino-3H-pyrimidine-4-one 
• 367518-78-3 6-[2’-deoxy-3’-O-dimethoxytrityl-β-D-ribofuranose-1’-yl]amino-5-nitro-2-(phenoxylacetyl)amino-3H-pyrimidine-4-one 

Relevant articles and documents

X-ray structure of 1,3,4-tri-O-acetyl-2-deoxy-β-d-erythro-pentopyranose

Peracetylated 2-deoxy-d-erythro-pentose (2-deoxy-d-ribose) was synthesized through the acetylation of 2-deoxy-d-ribose with acetic anhydride in pyridine, and the products (including all four ring forms) exist in form of either a white solid or a syrup. A

Method for synthesizing decitabine key intermediate by solid acid catalysis

The invention belongs to the technical field of medicinal chemistry, and relates to a method for synthesizing a decitabine key intermediate (formula II) by solid acid catalysis. The method is characterized in that silicon dioxide loaded stannic chloride (SnCl4) is used as a catalyst for glycosylation reaction. The method has the advantages that the problem of complicated post treatment of a liquidacid catalyst is solved, and the content of beta-configuration intermediate can be effectively improved.

Synthesis of 2-deoxy ribose related disaccharide nucleoside and its phosphoramidite

Synthesis of impurity reference compound of anti-tumor drug ISIS 183750 was achieved. In this process, a general method for synthesis of 2-deoxy ribosyl disaccharide nucleosides was established for the first time.