459422-07-2

Basic information

• Product Name: 9-(4-bromophenyl)-6,6-dimethyl-5,6,7,9-tetrahydro-[1,2,4]triazolo[5,1-b]quinazolin-8(4H)-one
• Synonyms: 9-(4-bromophenyl)-6,6-dimethyl-5,6,7,9-tetrahydro-[1,2,4]triazolo[5,1-b]quinazolin-8(4H)-one
• CAS NO: 459422-07-2
• Molecular Weight: 373.252
• Mol File: 459422-07-2.mol

Chemical Properties

• CAS DataBase Reference: 9-(4-bromophenyl)-6,6-dimethyl-5,6,7,9-tetrahydro-[1,2,4]triazolo[5,1-b]quinazolin-8(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 9-(4-bromophenyl)-6,6-dimethyl-5,6,7,9-tetrahydro-[1,2,4]triazolo[5,1-b]quinazolin-8(4H)-one(459422-07-2)
• EPA Substance Registry System: 9-(4-bromophenyl)-6,6-dimethyl-5,6,7,9-tetrahydro-[1,2,4]triazolo[5,1-b]quinazolin-8(4H)-one(459422-07-2)

Safety Data

• Hazardous Substances Data: 459422-07-2(Hazardous Substances Data)

Upstream product

• 61-82-5 3⁽⁵⁾-amino-1,2,4-triazole 
• 126-81-8 dimedone 
• 1122-91-4 4-bromo-benzaldehyde 
• 61-82-5 3-amino-1,2,4-triazole 

Relevant articles and documents

An efficient, one-pot three components synthesis of [1,2,4] triazoloquinazolinone derivatives using anthranilic acid as green catalyst

A simple, efficient and convenient approach has been reported for the synthesis of quinazolines by the condensation of 3-amino, 1,2,4-triazole with dimedone and different aromatic aldehydes in the presence of anthranilic acid as a catalyst through a one-p

Design and synthesis of nickel tetra‐2,3‐pyridiniumporphyrazinato trinitromethanide as an influential catalyst and its application in the synthesis of 1,2,4-triazolo based compounds

The facile and benign syntheses of [1,2,4]triazolo[5,1-b]quinazolines and [1,2,4]triazolo[1,5-b]pyrimidines were studied using novel nickel tetra‐2,3‐pyridiniumporphyrazinato trinitromethanide [Ni(TPPAH)][C(NO2)3]4 as an e

Silica-coated magnetic nanoparticles containing bis dicationic bridge for the synthesis of 1,2,4-triazolo pyrimidine/ quinazolinone derivatives

In this work and for the first time, the preparation of bis-[(3-aminopropyl)triethoxysilane]dichloride immobilized on magnetic nano γ-Fe2O3&at;SiO2 via the reaction of two molecules of 3-aminopropyl)triethoxysilane with 1,

Preparation and characterization of a novel DABCO based tetra cationic ionic liquid as a reusable catalyst for the multi-component synthesis of 2H-indazolo[2,1-b]phthalazine-trione and [1,2,4]triazoloquinazolinone derivatives under solvent-free condition

In current study, a new DABCO based tetra cationic ionic liquid, formulated as [C4(H-DABCO)2][HSO4]4 is easily prepared and characterized using FT-IR, 1H NMR,13C NMR, TGA, and DTG analysis, and also pH-metric titration method. In continue, the efficiency of the prepared catalyst in the acceleration of the synthesis of 2H-indazolo[2,1-b]phthalazine-trione and [1,2,4]triazoloquinazolinone derivatives, is investigated. Simple experimental procedure, using available and low-cost starting materials for the preparation of the catalyst, reusability of the catalyst, isolation of products without using chromatographic methods, short reaction times, high isolated yields, and solvent-free conditions are the most important features of the present method.

Efficiency of NaHSO4 modified periodic mesoporous organosilica magnetic nanoparticles as a new magnetically separable nanocatalyst in the synthesis of [1,2,4]triazolo quinazolinone/pyrimidine derivatives

Immobilized NaHSO4 on core/shell phenylene bridged Periodic mesoporous organosilica magnetic nanoparticles (γ-Fe2O3@Ph-PMO-NaHSO4) as a new acidic magnetically separable nanocatalyst was successfully prepared in three steps: (i) preparation of γ-Fe2O3 nanoparticles by a precipitation method, (ii) synthesis of an organic-inorganic periodic mesoporous organosilica structure with phenyl groups on the surface of γ-Fe2O3 magnetic nanoparticles (MNPs) and (iii) finally adsorption of NaHSO4 on periodic mesoporous organosilica (PMO) network. The results of N2 adsorption-desorption isotherms, XRD and TEM showed formation of the Periodic mesoporous organosilica magnetic nanocomposite with the uniform size up to 15 nm. The efficiency of the new catalyst was evaluated in promoting the synthesis of [1,2,4]triazolo quinazolinone/pyrimidine derivatives as important biologically active compounds. Eco-friendly protocol, high yields, short reaction times, reusability of the catalyst and easy and quick isolation of the products are the main advantages of this procedure.

A simple and convenient synthesis of [1,2,4]triazolo/benzimidazolo quinazolinone and [1,2,4]triazolo[1,5-a]pyrimidine derivatives catalyzed by DABCO-based ionic liquids

DABCO-based ionic liquids were utilized for the preparation of [1,2,4]triazolo/benzimidazolo quinazolinone and [1,2,4]triazolo[1,5-a]pyrimidine derivatives in the adequate procedures. These methods involve three-component reaction between aldehydes, β-dik

Nickel nanoparticles assisted regioselective synthesis of pyrazoloquinolinone and triazoloquinazolinone derivatives

Biologically important pyrazoloquinolinone and triazoloquinazolinone derivatives were synthesized by the condensation reaction of 3-amino-1H-1,2,4-triazole/3-amino-5-methyl-1H-pyrazole, dimedone and aryl aldehydes using catalytic amount of magnetically re

A simple, convenient one-pot synthesis of [1,2,4]triazolo/benzimidazolo quinazolinone derivatives by using molecular iodine

A wide variety of quinazolinone derivatives have been synthesized by condensation of 3-amino-1,2,4-triazole and 2-aminobenzimidazole as amine sources, with aromatic aldehydes and dimedone in the presence of 10 mol % of molecular iodine in acetonitrile und

Sulfamic acid-catalyzed, three-component, one-pot synthesis of [1,2,4]Triazolo/benzimidazolo quinazolinone derivatives

An efficient and convenient approach is reported for three-component, one-pot synthesis of the [1,2,4]triazolo/benzimidazolo quinazolinones by condensation of 2-amino benzimidazole or 3-amino-1,2,4-triazole as amine sources with dimedone and different ald