459426-22-3

Basic information

• Product Name: 15-biotinlaMino-4,7,10,13-dioxanonanoic acid N-hydroxysucciniMidyl ester
• Synonyms: 15-biotinlaMino-4,7,10,13-dioxanonanoic acid N-hydroxysucciniMidyl ester;Biotin-PEG4-NHS;Biotin-PEG4-CH2CH2COONHS Ester;21-[(3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-17-oxo-4,7,10,13-tetraoxa-16-azaheneicosanoic acid 2,5-dioxo-1-pyrrolidinyl ester;Biotin-PEG4-NHS ester;Biotin PEG4 succinimidyl ester;NHS-dPEG(R)4-biotin
• CAS NO: 459426-22-3
• Molecular Formula: C25H40N4O10S
• Molecular Weight: 588.6709
• Mol File: 459426-22-3.mol

Chemical Properties

• Appearance: /
• Density: 1.33±0.1 g/cm3(Predicted)
• Storage Temp.: -20°C
• Solubility: Soluble in DMSO, DMF, DCM
• PKA: 13.90±0.40(Predicted)
• CAS DataBase Reference: 15-biotinlaMino-4,7,10,13-dioxanonanoic acid N-hydroxysucciniMidyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 15-biotinlaMino-4,7,10,13-dioxanonanoic acid N-hydroxysucciniMidyl ester(459426-22-3)
• EPA Substance Registry System: 15-biotinlaMino-4,7,10,13-dioxanonanoic acid N-hydroxysucciniMidyl ester(459426-22-3)

Safety Data

• Hazardous Substances Data: 459426-22-3(Hazardous Substances Data)

Usage

Uses

Used in Biochemical Research:
Biotin-PEG4-NHS is used as a biotinylation reagent for the modification of proteins and antibodies. The incorporation of biotin enables the specific recognition and detection of these biomolecules through the high-affinity interaction with avidin or streptavidin. This is particularly useful for various applications, such as enzyme-linked immunosorbent assays (ELISA), Western blotting, and immunoprecipitation.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Biotin-PEG4-NHS can be used as a component in the development of targeted drug delivery systems. The biotinylation of drug molecules or carriers with Biotin-PEG4-NHS can facilitate their specific binding to avidin or streptavidin-coated surfaces or nanoparticles, allowing for enhanced selectivity and controlled release of the therapeutic agents.
Used in Diagnostic Applications:
Biotin-PEG4-NHS is also employed in the development of diagnostic tools, such as lateral flow assays and biosensors. The biotinylation of target molecules or detection antibodies with Biotin-PEG4-NHS allows for their specific detection through the interaction with avidin or streptavidin-labeled probes, providing a sensitive and reliable method for the detection of various analytes.
Used in Cell Biology:
In cell biology, Biotin-PEG4-NHS can be utilized for the biotinylation of cell surface proteins or lipids, enabling their specific labeling and tracking within cells. This can be particularly useful for studying cellular processes, such as membrane trafficking, protein-protein interactions, and cell signaling pathways.
Overall, 15-biotinlaMino-4,7,10,13-dioxanonanoic acid N-hydroxysucciniMidyl ester (Biotin-PEG4-NHS) is a valuable reagent in various fields, including biochemistry, molecular biology, pharmaceuticals, diagnostics, and cell biology, due to its ability to facilitate the coupling of biotin to primary amines and its compatibility with a wide range of applications.