45982-66-9

Usage

Molecular structure

1,4-Dioxaspiro[4.5]decane-2-methanamine has a complex molecular structure with two fused rings (a spiro compound) that share a single atom.

Derivative of spiro compounds

This chemical compound is derived from spiro compounds, which are known for their unique structure and properties.

Amine functional group

The presence of the amine functional group (-NH2) indicates that the compound contains a nitrogen atom, which can affect its reactivity and properties.

Upstream product

• 108-94-1 cyclohexanone 
• 247226-17-1 N-(1,4-dioxaspiro[4,5]dec-2-ylmethyl)acetamide 

Downstream Products

• 40580-59-4 Guanadrel 
• 247226-18-2 N-(1,4-Dioxaspiro[4,5]dec-2-ylmethyl)-N',N''-bis(benzyloxycarbonyl)guanidine 

Relevant academic research and scientific papers

N-Hydroxyl derivatives of guanidine based drugs as enzymatic NO donors

Recent research suggests that NO may play a role in the physiological effects of some guanidine-containing drugs. In this report, three guanidine-containing drugs (guanadrel, guanoxan, and guanethidine) together with their N-hydroxyl derivatives were synthesized and their NO-releasing abilities catalyzed by nitric oxide synthases (NOSs) and horseradish peroxidase were evaluated. The guanidine containing compounds could not release NO in the presence of NOS or peroxidase. The corresponding N-hydroxyl compounds exhibited weak NO-releasing ability under the catalyzed of NOS and good NO-releasing ability under the oxidation by horseradish peroxidase in the presence of H2O2. These compounds also displayed vasodilatory activity. Elsevier Science Ltd. All rights reserved.

Synthesis of biologically important guanidine-containing molecules using triflyl-diurethane protected guanidines

The guanidine-containing biologically important molecules, guanadrel, guanoxan, guanethidine and smimovine have been synthesized using the recently developed triflyl-diurethane protected guanidines.