459832-87-2

Upstream product

• 72155-45-4 Boc-L-phenylalaninal 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 244033-83-8 (4S)-4-N-benzylamino-5-phenyl-2-trans-pentenoic acid, ethyl ester 
• 244033-75-8 (S)-(+)-trans-5-phenyl-4-amino-2-pentenoic acid ethyl ester 
• 124818-94-6 ethyl (2E,4S)-4-[(tert-butoxycarbonyl)amino]-5-phenylpent-2-enoate 
• 459833-02-4 4-[benzyl-(4-oxo-pent-2-enoyl)-amino]-5-phenyl-pent-2-enoic acid ethyl ester 
• 87694-53-9 Boc-Phe-OH N,O-dimethyl hydroxamate 

Relevant academic research and scientific papers

An intramolecular oxo Diels-Alder approach to 1-oxo-1,2,3,3a,4,7a- hexahydro-pyrano[3,4-c]pyrrole-4-carboxylic acid ethyl esters

The diastereoselective synthesis of a series of 1-oxo-1,2,3,3a,4,7a- hexahydro-pyrano[3,4-c]pyrrole-4-carboxylic acid ethyl esters via an oxo Diels-Alder reaction is described. Ab initio calculations predicted the products of the exo cycloaddition to be the thermodynamic products while the products resulting from the endo cycloaddition were predicted to be the kinetic products. The calculations were born out by experimental data.

Methods for the synthesis of densely functionalized pyrrolidine intermediates

This invention is directed to methods of synthesizing densely functionalized pyrrolidine compounds through the use of intramolecular Diels Alder reactions.

Synthesis of densely functionalized pyrrolidinone templates by an intramolecular oxo-Diels-Alder reaction

Preparation of densely functionalized pyrrolidinone templates, is a challenge for synthetic chemists. These templates are important building blocks for novel conformationally constrained natural products or for library generation of highly functionalized