459835-97-3Relevant academic research and scientific papers
5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition
Auberson, Yves P,Allgeier, Hans,Bischoff, Serge,Lingenhoehl, Kurt,Moretti, Robert,Schmutz, Markus
, p. 1099 - 1102 (2002)
NMDA antagonists derived from 5-phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione (3a) are potent anticonvulsant agents, and display strong protective effects in the electroshock-induced convulsion assay in mice. Their preference for the human NMDAR 1A/2A over 1A/2B subunit composition was optimized, leading to (1RS,1′S)-PEAQX (9r), which shows a >100-fold selectivity.
