45985-26-0

Upstream product

• 826-36-8 2,2,6,6-Tetramethyl-4-piperidone 
• 3637-11-4 1-hydroxy-2,2,6,6-tetramethyl-piperidin-4-one 
• 2154-65-6 1,3,5-triphenylverdazyl 
• 97871-97-1 2-(p-tolyl)-4,6-diphenyl-3,4-dihydro-1,2,4,5-tetrazin-1(2H)-yl 
• 42391-54-8 2-<4-chlorophenyl>-4,6-diphenylverdazyl 
• 42450-45-3 2-(4-methoxyphenyl)-4,6-diphenyl-3,4-dihydro-1,2,4,5-tetrazin-1(2H)-yl 
• 29872-18-2 2-(4-nitrophenyl)-4,6-phenyl-3,4-dihydro-1,2,4,5-tetrazin-1(2H)-yl 
• 99910-02-8 C₂₁H₁₈N₅O₃ 
• 99910-01-7 2-(p-methoxyphenyl)-4-phenyl-6-(p-nitrophenyl)-3,4-dihydro-2H-sym-tetrazin-1-yl 
• 2564-83-2 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical 
• 95407-69-5 4-methoxy-2,2,6,6-tetramethylpiperidin-1-oxyl radical 
• 32889-28-4 2,2,6,6-Tetramethyl-4-oxo-1-hydroxypiperidinium-perchlorat 
• 22963-71-9 1-hydroxy-4-oxo-2,2,6,6-tetramethylpiperidine hydrochloride 
• 137003-52-2 <15N>-2,2,6,6-tetramethyl-4-piperidone 

Downstream Products

• 3637-11-4 1-hydroxy-2,2,6,6-tetramethyl-piperidin-4-one 
• 1227476-15-4 Azobenzene 
• 22963-71-9 1-hydroxy-4-oxo-2,2,6,6-tetramethylpiperidine hydrochloride 
• 15871-56-4 2',5'-Dioxo-2,2,6,6-tetramethyl-piperidin-(4-spiro-4')-imid-azolidin-oxyl-(1) 
• 73645-89-3 4-hydroxy-4-(p-ethynylphenylethynyl)-2,2,6,6-tetramethylpiperidin-1-oxyl 
• 45985-24-8 TEMPOL 
• 77874-89-6 2,2,6,6-tetramethyl-3-methoxycarbonyl-4-piperidone-1-oxyl 
• 46147-12-0 3-carbamoyl-2,2,5,5-tetramethylpyrrolidin-1-yloxy 
• 700-58-3 2-Adamantanone 
• 21898-84-0 4-oxohomoadamantan-5-one 
• 56820-19-0 bicyclo<3.3.1>non-6-ene-3-endo-carboxylic acid 
• 104725-63-5 4-phenoxymethyl-4-hydroxy-2,2,6,6-tetramethyl-1-piperidinyloxyl radical 
• 104725-68-0 4-<4-methylphenoxymethyl>-4-hydroxy-2,2,6,6-tetramethyl-1-piperidinyloxyl radical 
• 104725-67-9 4-<4'-chlorophenoxymethyl>-4-hydroxy-2,2,6,6-tetramethyl-1-piperidinyloxyl radical 

Relevant academic research and scientific papers

Ultrathin 2D Zirconium Metal–Organic Framework Nanosheets: Preparation and Application in Photocatalysis

Synthesizing ultrathin 2D metal–organic framework nanosheets in high yields has received increasing research interest but remains a great challenge. In this work, ultrathin zirconium-porphyrinic metal–organic framework (MOF) nanosheets with thickness down to ≈1.5 nm are synthesized through a pseudoassembly–disassembly strategy. Owing to the their unique properties originating from their ultrathin thickness and highly exposed active sites, the as-prepared ultrathin nanosheets exhibit far superior photocatalysis performance compared to the corresponding bulk MOF. This work highlights new opportunities in designing ultrathin MOF nanosheets and paves the way to expand the potential applications of MOFs.

Method for preparing hindered amine nitroxide free radical compound by alkaline heterogeneous catalysis system

The method comprises the following steps: dissolving a hindered amine compound in an organic solvent; adjusting pH by a carbonate aqueous solution; reacting with an aqueous hydrogen peroxide solution; and generating a hindered amine nitroxide free radical compound (IV). (V) Or (VI). The method is high in universality, and the hindered amine nitroxide free radical compound with various structures is prepared. The method is high in catalytic activity, short in reaction time, high in yield, simple in preparation process and convenient to operate; a high-purity target product can be obtained through simple phase separation, drying and concentration in the post-treatment process; meanwhile, the aqueous solution system and ethyl acetate can be recycled. Small by-products.

Spin-labeled naphthalimide oxygen-containing compound and application thereof

The invention belongs to the technical field of medical drugs, and relates to a spin-labeled naphthalimide compound containing an oxygen substituent and an application thereof, in particular to a stable nitroxide free radical labeled naphthalimide compound containing an oxygen substituent and an application thereof in preparation of anti-tumor drugs. According to the spin-labeled naphthalimide oxygen-containing compound and the application thereof, a stable nitroxide free radical is introduced into an oxygen-containing substituent naphthalimide parent to obtain the naphthalimide compound shown in the general formula I and pharmaceutically acceptable salt thereof, and the compound has good anti-tumor activity, shows lower toxicity to normal cells than a naphthalimide analogue containing a nitrogen substituent, and has very good development and application prospects.

Preparation method for synthesizing polymerization inhibitor 702 from acetone and ammonia gas through one-pot method

The invention belongs to the technical field of polymerization inhibitor synthesis, and discloses a preparation method for synthesizing a polymerization inhibitor 702 from acetone and ammonia gas through a one-pot method. The preparation method comprises the following steps: adding acetone and a carrier catalyst into a reaction kettle, introducing ammonia gas, and conducting reacting at 50-60 DEG C for 2-6 hours; and then adding deionized water and hydrogen peroxide, conducting reacting at 15-40 DEG C for 1-3 hours, filtering the reaction solution, and carrying out reduced-pressure distillation on the obtained filtrate to obtain the polymerization inhibitor 702. According to the invention, reaction conditions are mild, the preparation method is simple and convenient, the carrier catalyst is easy to separate, and product yield is high.

A class of stable nitroxide free radical modified naphthalimide compounds, and application thereof

The invention belongs to the technical field of medicines, and relates to a class of naphthalimide compounds modified by stable nitroxide free radicals, and application thereof, particularly to a class of naphthalimide compounds with stable nitroxide free radicals, and application of the naphthalimide compounds in preparation of antitumor medicines. According to the invention, stable nitroxide free radicals are introduced into a naphthalimide parent structure to obtain a naphthalimide compound represented by a general formula I or II, and a pharmaceutically acceptable salt, a solvate and a hydrate thereof, wherein R1, R2, R3 and R4 are defined in the claims and the specification.

Mussel-inspired preparation of C60 nanoparticles as photo-driven DNA cleavage reagents

Designing and constructing favorable water-dispersible fullerenes and their derivatives are of huge importance for biological applications addressing DNA-cleavage and photodynamic therapy (PDT). In the present work, a mild, green and facile synthetic approach for the preparation of C60 nanoparticles was developed for the first time via the combination of mussel-inspired chemistry and the Michael addition reaction. The resultant C60-PDA-PEI nanoparticles were characterized by transmission electron microscopy (TEM), dynamic laser scattering (DLS), Fourier-transform infrared spectroscopy (FT-IR), Raman spectra, X-ray photoelectron spectra (XPS) and thermogravimetric analysis (TGA), demonstrating that the above two-step strategy allows easy access to the preparation of highly water-dispersible fullerene derivatives. Benefiting from their unique nanostructure, the versatile C60-PDA-PEI nanoparticles display a uniform hydrodynamic size of 160 nm in water and efficient 1O2 generation under irradiation. Furthermore, the good ability of cleaving DNA under visible light at a mass concentration of 62.5 ng μL-1 gives them high potential as PDT agents. The universal approach described in this work is capable of introducing many other functional molecules onto PDA-modified fullerenes, thus extending the possible applications of fullerene-based species in many fields of biotechnology and pharmaceutical chemistry.

Titanium-Carboxylate Metal-Organic Framework Based on an Unprecedented Ti-Oxo Chain Cluster

Titanium(IV)-based metal-organic frameworks (Ti-MOFs) have received significant attention in recent years due to their numerous photocatalytic applications. We herein prepare the single-crystalline Ti-carboxylate MOF (DGIST-1) composed of an unprecedented Ti-oxo chain cluster and the porphyrinic ligand, TCPP (tetrakis(4-carboxyphenyl)porphyrin). Preformed Ti-oxo clusters were used as Ti4+ sources to avoid the spontaneous hydrolysis and condensation reactions of traditional Ti-alkoxide precursors, thus, enabling the formation of the highly crystalline Ti-MOF. The successfully activated DGIST-1 exhibited a higher surface area (i.e., 1957.3 m2 g?1) than previously reported Ti-MOFs due to its high crystallinity. Furthermore, the visible-light-responsive photocatalytic activity of DGIST-1 was confirmed by the simultaneous generation of singlet oxygen (1O2) and superoxide (.O2?) species, in addition to the highly efficient and selective oxidation of benzyl alcohol to benzaldehyde.

Nickel-Catalyzed Aminoxylation of Inert Aliphatic C(sp3)-H Bonds with Stable Nitroxyl Radicals under Air: One-Pot Route to α-Formyl Acid Derivatives

Nickel-catalyzed aminoxylation of an unactivated C(sp3)-H bond with a stable nitroxyl radical has been accomplished for the first time to offer various N-alkoxyamine derivatives, which further enables a one-pot approach to α-formyl acid derivatives. The aminoxylation process reported also provides direct evidence for the oxidative addition of a cyclometallic intermediate with a free radical, which is helpful for the reaction-mechanism study in transition-metal-catalyzed functionalization of inert C(sp3)-H bonds.

Singlet oxygen generation properties of an inclusion complex of cyclic free-base porphyrin dimer and fullerene C60

To gain insight into the singlet oxygen (1O2) generation properties of supramolecular complexes of cyclic free-base porphyrin dimer with fullerene C60, we evaluated the 1O2 quantum yield (ΦΔ) and rate constant (Kobs) of 1O2 generation for a cyclic free-base porphyrin dimer (CPD) linked by butadiyne bearing four 4-pyridyl groups and its inclusion complex (C60?CPD) with C60. We demonstrate that CPD and C60?CPD possess the ability to generate 1O2 under visible light irradiation. Moreover, it was found that the ΦΔ value of C60?CPD is lower than that of CPD. Based on the kinetic and thermodynamic consideration concerning the electron transfer processes between the porphyrin dimer and C60, this work revealed that the lower ΦΔ value of the C60 inclusion complex would be attributed to the formation of the charge-separated state c60·?-CPD·+, leading to a low intersystem crossing (ISC) efficiency for the formation of the triplet excited state 3(CPD)*.

Synthesis and fluorescence properties of six fluorescein-nitroxide radical hybrid-compounds

Six fluorescein-nitroxide radical hybrid-compounds (2ab, 3ab, 4, and 5) were synthesized by the condensation of 5- or 6-carboxy-fluorescein and 4-amino-TEMPO (2ab), 5- or 6-aminofluorescein and 4-carboxy-TEMPO (3ab), and fluorescein and 4-carboxy-TEMPO (4), or by reaction of the 3-hydroxyl group of fluorescein with DPROXYL-3-ylmethyl methanesulfonate (5). Fluorescence intensities (around 520 nm) after reduction of the radical increased to 1.43-, 1.38-, and 1.61-folds for 2a, 2b and 3b respectively; 3a alone exhibited a decrease in intensity on reduction. Since 4 was readily solvolyzed in PBS or even methanol to afford fluorescein and 4-carboxy-TEMPO, its fluorescence change could not be measured. Hybrid compound 5 containing an ether-linkage between the fluorescein phenol and 3-hydroxymethyl-DPROXYL hydroxyl centers, was stable and on reduction, showed a maximum increase (3.21-fold) in relative fluorescence intensity in PBS (pH 5.0), despite its remarkably low absolute fluorescence intensity.