45990-12-3Relevant academic research and scientific papers
Tunable and Cooperative Catalysis for Enantioselective Pictet-Spengler Reaction with Varied Nitrogen-Containing Heterocyclic Carboxaldehydes
Chan, Yuk-Cheung,Frank, Scott A.,Miller, Scott J.,Sak, Marcus H.
supporting information, p. 24573 - 24581 (2021/10/12)
Herein we report an organocatalytic enantioselective functionalization of heterocyclic carboxaldehydes via the Pictet–Spengler reaction. Through careful pairing of novel squaramide and Br?nsted acid catalysts, our method tolerates a breadth of heterocycle
Formal Deoxygenative Hydrogenation of Lactams Using PNHP-Pincer Ruthenium Complexes under Nonacidic Conditions
Ogata, Osamu,Nara, Hideki,Matsumura, Kazuhiko,Kayaki, Yoshihito
supporting information, p. 9954 - 9959 (2019/12/24)
A formal deoxygenative hydrogenation of amides to amines with RuCl2(NHC)(PNHP) (NHC = 1,3-dimethylimizadol-2-ylidene, PNHP = bis(2-diphenylphosphinoethyl)amine) is described. Various secondary amides, especially NH-lactams, are reduced with H2 (3.0-5.0 MPa) to amines at a temperature range of 120-150 °C with 1.0-2.0 mol % of PNHP-Ru catalysts in the presence of Cs2CO3. This process consists of (1) deaminative hydrogenation of secondary amides to generate primary amines and alcohols, (2) dehydrogenative coupling of the transient amines with alcohols to generate imines, and (3) hydrogenation of imines to give the formally deoxygenated secondary amine products.
Pharmaceutically active compounds and methods of use
-
, (2008/06/13)
The present invention relates to pharmaceutically acceptable compounds, including certain substituted indolinyl and derivatives thereof, 1,2,3,4-tetrahydroquinolinyl and derivatives thereof, 1,2,3,4-tetrahydroisoquinolinyl, benz[cd]indolinyl and 5,6-dihyd
