46001-36-9

Usage

Uses

Used in Research Applications:
8-Fluoro-2-Methyl-Quinoline is used as a research compound for studying its chemical properties and potential applications in various fields. Its unique molecular structure allows researchers to explore its interactions with other molecules and its potential use in the development of new materials or pharmaceuticals.
Used in Chemical Industry:
8-Fluoro-2-Methyl-Quinoline is used as an intermediate or building block in the synthesis of more complex molecules in the chemical industry. Its quinoline ring structure and functional groups make it a valuable component in the production of various chemical products, such as pharmaceuticals, agrochemicals, or dyes.
Used in Pharmaceutical Development:
8-Fluoro-2-Methyl-Quinoline is used as a potential candidate in the development of new pharmaceuticals. Its heterocyclic aromatic properties and specific molecular structure may contribute to the design of novel drugs with improved therapeutic effects or reduced side effects.
Used in Material Science:
8-Fluoro-2-Methyl-Quinoline is used as a component in the development of new materials with unique properties. Its quinoline ring structure and functional groups can be incorporated into the design of advanced materials, such as organic semiconductors, sensors, or catalysts, for various applications in electronics, energy, or environmental protection.

Upstream product

• 348-54-9 2-Fluoroaniline 
• 123-73-9 crotonaldehyde 
• 66023-21-0 2-methyl-6-(trifluoromethyl)-quinoline 
• 123-73-9 trans-Crotonaldehyde 

Downstream Products

• 914208-13-2 8-fluoroquinoline-2-carboxylic acid 
• 168083-16-7 3-(8-fluoro-2-quinolinylmethoxy)aniline 

Relevant academic research and scientific papers

Synthesis of palladium complexes with quinolino-based tridentate ligands and their applications for norbornene polymerization

Palladium complexes bearing new tridentate quinolino-based [N?NNox] ligands were synthesized and tested for the polymerization of norbornene. Upon activation of MAO, all the palladium complexes showed high catalytic activities for th

INHIBITORS OF RPN11

Candidate compounds for specific inhibition of Rpn11 are represented by Formula 1a where each of R2, R3, R4, R5, R6, and R7 is independently selected from hydrogen (H), substituted and unsubstituted alkyl groups, carboxyl groups, or substituted and unsubstituted carboxyamides.

Discovery of an Inhibitor of the Proteasome Subunit Rpn11

The proteasome plays a crucial role in degradation of normal proteins that happen to be constitutively or inducibly unstable, and in this capacity it plays a regulatory role. Additionally, it degrades abnormal/damaged/mutant/misfolded proteins, which serves a quality-control function. Inhibitors of the proteasome have been validated in the treatment of multiple myeloma, with several FDA-approved therapeutics. Rpn11 is a Zn2+-dependent metalloisopeptidase that hydrolyzes ubiquitin from tagged proteins that are trafficked to the proteasome for degradation. A fragment-based drug discovery (FBDD) approach was utilized to identify fragments with activity against Rpn11. Screening of a library of metal-binding pharmacophores (MBPs) revealed that 8-thioquinoline (8TQ, IC50 value ～2.5 μM) displayed strong inhibition of Rpn11. Further synthetic elaboration of 8TQ yielded a small molecule compound (35, IC50 value ～400 nM) that is a potent and selective inhibitor of Rpn11 that blocks proliferation of tumor cells in culture.

Quinoline-derived two-photon sensitive quadrupolar probes

The first quadrupolar 8-dimethylaminoquinoline-derived 6-(8-DMAQ-OAc)2 (1c) and 5-(8-DMAQ-OAc)2 (2c) photosensitive probes underwent photolysis under UV (365 nm) and NIR (730 nm two-photon (TP)) irradiation conditions, showing Q

COMPOSITIONS AND METHODS FOR JAMM PROTEIN INHIBITION

Compounds, pharmaceutical compositions, and methods of using such compounds to treat or prevent diseases or disorders associated with or mediated by JAMM proteins are disclosed.

High throughput one pot synthesis of 2-methylquinolines

Various 2-methylquinolines have been successfully synthesized by using anilines and ethyl vinyl ether in 1:3 mole ratios in the presence of acetic acid. Stirring at rt for 3-4 h followed by reflux for 3.5-4 h resulted in the corresponding 2-methylquinolines in good yield. Copyright

QU1NOLINE DERIVATIVES AND THEIR USES FOR RHINITIS AND URTICARIA

The present invention relates to compounds of formula (I) and salts thereof, processes for their preparation, to compositions containing them and to their use in the treatment of various diseases, such as allergic rhinitis.

Novel N-acylated heterocycles

Described are compositions comprising a muscarinic receptor antagonist and an N-acylated heterocycle derivative having affinity for serotonergic receptors, and enantiomers, diastereoisomers, N-oxides, polymorphs, solvates and pharmaceutically acceptable salts thereof. The combination of a muscarinic receptor antagonist and an N-acylated heterocycle, or an enantiomer, diastereoisomer, N-oxide, polymorph, solvate or pharmaceutically acceptable salt thereof, is useful in the treatment of patients with neuromuscular dysfunction of the lower urinary tract and diseases related to 5-HT1A receptors.

Preparation and evaluation of sulfur-containing metal chelators

With a view to probe the structure and function of G-protein coupled receptors the synthesis of functionalized 8-mercaptoquinoline derivatives and 2-(2-pyridyl)thiophenol was achieved. A fluorescence-based method for determining the affinity of these metal chelators toward zinc ions was developed.

Quinoline compound

Compounds of formula I STR1 wherein R1 -R5, X, Ar and Y are as defined in the description, have valuable pharmaceutical properties and are especially effective as leukotriene antagonists. They are prepared in a manner known per se.