460041-64-9

Upstream product

• 195191-58-3 (E)-3-(2-aminophenyl)prop-2-en-1-ol 
• 1504-65-0 2-nitrocinnamyl alcohol 
• 460041-63-8 (E)-N-[2-(3-hydroxyprop-1-enyl)phenyl]-2-amino-1,4-naphthoquinone 

Downstream Products

• 460041-71-8 (E)-N-[2-(3-N'-phenylhydrazonoprop-1-enyl)phenyl]-2-amino-1,4-naphthoquinone 

Relevant academic research and scientific papers

Intramolecular Michael-type addition of azadienes to 1,4-naphthoquinones instead of Aza-Diels-Alder cycloaddition: A synthesis of ascididemin

α,β-Unsaturated hydrazones tethered by an amino group to 1,4-naphthoquinone or quinoline-5,8-dione do not react by intramolecular aza-Diels-Alder cycloaddition. Instead, these substrates cyclize to form benzo[b]acridine-6,11-dione or pyrido[2,3-b]acridine-5,12-dione derivatives, respectively. This route leads to a highly concise synthesis of the pyridoacridine alkaloid ascididemin.