460048-41-3

Upstream product

• 359-07-9 2-bromo-1,1-difluoroethane 
• 89209-02-9 4,6-di-tert-butyl-2-iodophenol 
• 460087-88-1 2,4-Di-tert-butyl-1-(2,2-difluoro-ethoxy)-benzene 

Downstream Products

• 460048-26-4 [3,5-di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenylethynyl]-trimethyl-silane 
• 691888-21-8 1-{4-[3,5-di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-benzo[b]thiophen-2-yl}-ethanone 
• 460048-28-6 1,5-di-tert-butyl-2-(2,2-difluoro-ethoxy)-3-(2-iodo-1-methyl-vinyl)-benzene 
• 460048-27-5 {2-[3,5-di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-propenyl}-trimethyl-silane 
• 460048-31-1 (2E,4Z,6Z)-7-[3,5-Di-tert-butyl-2-(2,2-difluoro-ethoxy)-phenyl]-5-fluoro-3-methyl-octa-2,4,6-trienoic acid ethyl ester 

Relevant academic research and scientific papers

Retinoid x receptor modulators

The present invention is directed to compounds represented by Structural Formula (I) and pharmaceutically acceptable salts, solvates and hydrates thereof: (I). The invention is also directed to pharmaceutical compositions, methods of use and methods of making compounds represented by Structural Formula (I) and pharmaceutically acceptable salts, solvates and hydrates thereof.

Design, synthesis, and structure - Activity relationship studies of novel 6,7-locked-[7-(2-alkoxy-3,5-dialkylbenzene)-3-methylocta]-2,4,6-trienoic acids

Retinoid X receptor:peroxisome proliferative-activated receptor (RXR:PPAR) heterodimers play a critical role in the regulation of glucose (RXR/PPARγ) and lipid metabolism (RXR/PPARα). Previously, we described a concise structure-activity relationship stud

Design and synthesis of fluorinated RXR modulators

Fluorinated trienoic acid analogues of the RXR selective modulator 1 (LG101506) were synthesized, and tested for their ability to bind RXRα and activate RXR homo and heterodimers. Potency and efficacy were observed to be dependent upon the position of fluorination, and improvement in pharmacological profile was demonstrated in some cases.