460052-36-2

Usage

Uses

Used in Pharmaceutical Synthesis:
(R)-1-(2',3',4'-trichlorophenyl)ethanol is used as an intermediate in the pharmaceutical industry for the synthesis of various drugs. Its unique chemical structure allows it to serve as a building block in the development of new medications, contributing to the advancement of pharmaceutical research and innovation.
Used in Agrochemicals:
In the agrochemical industry, (R)-1-(2',3',4'-trichlorophenyl)ethanol is utilized for its insecticidal and antifungal properties. It helps protect crops from pests and diseases, ensuring higher yields and better quality produce, which is crucial for maintaining sustainable agricultural practices.
Used in Cancer Research:
(R)-1-(2',3',4'-trichlorophenyl)ethanol is being studied for its potential use in the treatment of various types of cancer. Its unique chemical properties make it a promising candidate for the development of novel therapeutic approaches, offering new possibilities for cancer patients and their treatment options.
Used in Alzheimer's Disease Research:
Additionally, (R)-1-(2',3',4'-trichlorophenyl)ethanol has been explored for its potential application in the treatment of Alzheimer's disease. Its involvement in this field of research highlights the compound's versatility and the ongoing efforts to find effective treatments for this debilitating condition.

Upstream product

• 1020073-57-7 (1R)-1-(2,3,4-trichlorophenyl)ethyl (2S,3S)-1-methyl-5-oxo-2-phenyltetrahydro-1H-pyrrolidine-3-carboxylate 
• 13608-87-2 2',3',4'-trichloroacetophenone 

Relevant academic research and scientific papers

Asymmetric reduction of halo-substituted arylalkanones with Rhizopus arrhizus

The Rhizopus arrhizus-mediated asymmetric reduction of various haloaryl alkanones furnished the respective (S)-carbinols with good to excellent enantioselectivities. It was found that the reaction course was primarily governed by the relative position of the halogen with respect to the carbonyl group, and its size. The relative order of efficacies of the nature of the halogen and their substitution pattern were Br > Cl > F and o- > p- > m-. The ortho-effect was the most predominant factor in the stereochemical outcome of the reaction, which was also confirmed with some non-halo-substituted acetophenones.

Enantiomers of (2R*,3R*)-1-methyl-5-oxo-2-phenyltetrahydro-1H-pyrrolidine-3-carboxylic acid as novel chiral resolving agents

A series of (2R*,3R*)-1-methyl-5-oxo-2-aryltetrahydro-1H-pyrrolidine-3-carboxylic acids were prepared and their structures were proven with X-ray crystallography. Racemic acid 5 has been resolved into enantiomers (2S,3S)-5 and (2R,3R)-5 by the formation of diastereomeric salts with brucine 9 and strychnidine 10, respectively. The ability of these enantiomers to serve as chiral discriminating agents was demonstrated by the chromatographic separation of diastereomeric amides and esters. Also, some preliminary results on the enantioselective reduction of prochiral imines with sodium borohydride modified by (2R,3R)-5 were collected.