460080-70-0Relevant articles and documents
Photoswitchable anticancer activity via trans-cis isomerization of a combretastatin A-4 analog
Sheldon, Jonathon E.,Dcona, M. Michael,Lyons, Charles E.,Hackett, John C.,Hartman, Matthew C. T.
, p. 40 - 49 (2015)
Combretastatin A-4 (CA4) is highly potent anticancer drug that acts as an inhibitor of tubulin polymerization. The core of the CA4 structure contains a cis-stilbene, and it is known that the trans isomer is significantly less potent. We prepared an azoben
PHOSPHODIESTERASE 4 INHIBITORS, INCLUDING N-SUBSTITUTED ANILINE AND DIPHENYLAMINE ANALOGS
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Page 54, (2008/06/13)
PDE4 inhibition is achieved by novel compounds, e.g., N-substituted aniline and diphenylamine analogs. The compounds of the present invention are of Formula (I): wherein R1, R2 R 3 and R4 are as defined herein.