460081-28-1

Basic information

• Product Name: 4-Oxazolecarboxylicacid,5-bromo-2-phenyl-,ethylester(9CI)
• Synonyms: 4-Oxazolecarboxylicacid,5-bromo-2-phenyl-,ethylester(9CI)
• CAS NO: 460081-28-1
• Molecular Formula: C₁₂H₁₀BrNO₃
• Molecular Weight: 0
• Product Categories: THIAZOLE
• Mol File: 460081-28-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Oxazolecarboxylicacid,5-bromo-2-phenyl-,ethylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Oxazolecarboxylicacid,5-bromo-2-phenyl-,ethylester(9CI)(460081-28-1)
• EPA Substance Registry System: 4-Oxazolecarboxylicacid,5-bromo-2-phenyl-,ethylester(9CI)(460081-28-1)

Safety Data

• Hazardous Substances Data: 460081-28-1(Hazardous Substances Data)

Upstream product

• 98-80-6 phenylboronic acid 
• 70-23-5 ethyl Bromopyruvate 
• 460081-18-9 ethyl 2-chloro-1,3-oxazole-4-carboxylate 
• 177760-52-0 ethyl 2-aminooxazole-4-carboxylate 
• 39819-39-1 2-phenyl-oxazole-4-carboxylic acid ethyl ester 

Downstream Products

• 939376-95-1 5-bromo-2-phenyl-oxazole-4-carboxylic acid 
• 460081-46-3 5-(3,4-dimethoxy-phenyl)-2-phenyl-oxazole-4-carboxylic acid 
• 70216-32-9 5-(3,4-dimethoxyphenyl)-2-phenyl-1,3-oxazole 
• 113923-95-8 2,5-diphenyl-4-vinyloxazole 
• 7007-08-1 4-bromo-2,5-diphenyloxazole 
• 573-34-2 2,4,5-triphenyloxazole 
• 18735-78-9 2,5-diphenyloxazole-4-carboxylic acid 
• 132198-53-9 2-phenyl-5H-[1,3]oxazolo[4,5-c]quinolin-4-one 
• 93729-29-4 ethyl 2,5-diphenyloxazole-4-carboxylate 
• 460081-31-6 ethyl 2-phenyl-5-(3,4-dimethoxyphenyl)oxazole-4-carboxylate 

Relevant articles and documents

Discovery and optimization of 2-phenyloxazole derivatives as diacylglycerol acyltransferase-1 inhibitors

In a discovery effort to find safe and effective DGAT-1 inhibitors, we have identified 2-phenyloxazole 4-carboxamide 1 as a conformationally constrained analog of a hydrazide hit, which was previously identified from high-throughput screening. Further optimization of this series has led to chemically more stable 2-phenyloxazole-based DGAT-1 inhibitor 25 with improved solubility, cell-based activity, and pharmacokinetic properties. Compound 25 also demonstrated in vivo efficacy in a diet-induced obesity (DIO) rat model.

Ethyl 2-chlorooxazole-4-carboxylate: A versatile intermediate for the synthesis of substituted oxazoles

(formula presented) R1 = Ar, Het, alkenyl R2 = H, Ar, Het, alkenyl, alkynyl R3 = H, CO2H, Ar, Het, alkenyl, alkynyl By using a sequence of regiocontrolled halogenation and palladium-catalyzed coupling reactions,