4-Methylumbelliferyl 2-Sulfamino-2-deoxy-α-D-glucopyranoside Sodium Salt is a synthetic compound that serves as a substrate for the lysosomal enzyme heparin sulfamidase. It is characterized by its ability to be hydrolyzed by the enzyme, resulting in the release of a fluorescent product, 4-methylumbelliferone. This property makes it a valuable tool in the development of fluorometric enzyme assays.
Used in Medical Research:
4-Methylumbelliferyl 2-Sulfamino-2-deoxy-α-D-glucopyranoside Sodium Salt is used as a fluorogenic substrate for the diagnosis of Sanfilippo disease type A (Mucopolysaccharidosis IIIA, MPS IIIA). This lysosomal storage disorder is caused by a deficiency of the enzyme heparin sulfamidase, which is responsible for the degradation of heparan sulfate. 4-Methylumbelliferyl 2-Sulfamino-2-deoxy-α-D-glucopyranoside Sodium Salt allows for the detection and measurement of the enzyme's activity in patient samples, aiding in the diagnosis and monitoring of the disease.
Used in Enzyme Assay Development:
4-Methylumbelliferyl 2-Sulfamino-2-deoxy-α-D-glucopyranoside Sodium Salt is used as a fluorogenic substrate in the development of enzyme assays for heparin sulfamidase. The assays are crucial for studying the enzyme's function, its role in the pathophysiology of Sanfilippo disease type A, and for evaluating the efficacy of potential therapeutic agents targeting the enzyme.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-Methylumbelliferyl 2-Sulfamino-2-deoxy-α-D-glucopyranoside Sodium Salt is used as a tool compound for the development of drugs targeting heparin sulfamidase. It can be employed in high-throughput screening assays to identify and optimize compounds that can potentially increase the enzyme's activity or compensate for its deficiency in Sanfilippo disease type A patients.
Used in Biochemical Education:
4-Methylumbelliferyl 2-Sulfamino-2-deoxy-α-D-glucopyranoside Sodium Salt can be used as an educational tool in biochemical courses and workshops. It provides students and researchers with hands-on experience in enzyme kinetics, enzyme assays, and the study of lysosomal storage disorders, enhancing their understanding of these complex biological processes.
Used in Medical Research:
4-Methylumbelliferyl 2-Sulfamino-2-deoxy-α-D-glucopyranoside Sodium Salt is used as a fluorogenic substrate for the diagnosis of Sanfilippo disease type A (Mucopolysaccharidosis IIIA, MPS IIIA). This lysosomal storage disorder is caused by a deficiency of the enzyme heparin sulfamidase, which is responsible for the degradation of heparan sulfate. 4-Methylumbelliferyl 2-Sulfamino-2-deoxy-α-D-glucopyranoside Sodium Salt allows for the detection and measurement of the enzyme's activity in patient samples, aiding in the diagnosis and monitoring of the disease.
Used in Enzyme Assay Development:
4-Methylumbelliferyl 2-Sulfamino-2-deoxy-α-D-glucopyranoside Sodium Salt is used as a fluorogenic substrate in the development of enzyme assays for heparin sulfamidase. The assays are crucial for studying the enzyme's function, its role in the pathophysiology of Sanfilippo disease type A, and for evaluating the efficacy of potential therapeutic agents targeting the enzyme.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-Methylumbelliferyl 2-Sulfamino-2-deoxy-α-D-glucopyranoside Sodium Salt is used as a tool compound for the development of drugs targeting heparin sulfamidase. It can be employed in high-throughput screening assays to identify and optimize compounds that can potentially increase the enzyme's activity or compensate for its deficiency in Sanfilippo disease type A patients.
Used in Biochemical Education:
4-Methylumbelliferyl 2-Sulfamino-2-deoxy-α-D-glucopyranoside Sodium Salt can be used as an educational tool in biochemical courses and workshops. It provides students and researchers with hands-on experience in enzyme kinetics, enzyme assays, and the study of lysosomal storage disorders, enhancing their understanding of these complex biological processes.
460085-45-4
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Basic information
- Product Name: 4-Methylumbelliferyl 2-Sulfamino-2-deoxy-α-D-glucopyranoside Sodium Salt
- Synonyms: 7-[[2-Deoxy-2-(sulfoaMino)-α-D-glucopyranosyl]oxy]-4-Methyl-;7-[[2-Deoxy-2-(sulfoamino)-alpha-D-glucopyranosyl]oxy]-4-methyl-2H-1-benzopyran-2-one monosodium salt;4-Methylumbelliferyl 2-deoxy-2-sulfamino-α-D-glucopyranoside sodium salt≥ 98% (HPLC);4-Mu-GlcNS;4-Methylumbelliferyl 2-Sulfamino-2-deoxy-α-D-glucopyranoside Sodium Salt;4-Methylumbelliferyl 2-deoxy-2-sulfamino-a-D-glucopyranoside sodium salt
- CAS NO:460085-45-4
- Molecular Formula: C16H18NNaO10S
- Molecular Weight: 439.36959
- EINECS: N/A
- Product Categories: Carbohydrates & Derivatives;Fluorescent Labels & Indicators;Labeling and Diagnostics Reagents
- Mol File: 460085-45-4.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
- Solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- Stability: Hygroscopic
- CAS DataBase Reference: 4-Methylumbelliferyl 2-Sulfamino-2-deoxy-α-D-glucopyranoside Sodium Salt(CAS DataBase Reference)
- NIST Chemistry Reference: 4-Methylumbelliferyl 2-Sulfamino-2-deoxy-α-D-glucopyranoside Sodium Salt(460085-45-4)
- EPA Substance Registry System: 4-Methylumbelliferyl 2-Sulfamino-2-deoxy-α-D-glucopyranoside Sodium Salt(460085-45-4)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 460085-45-4(Hazardous Substances Data)
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Check Digit Verification of cas no
The CAS Registry Mumber 460085-45-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,6,0,0,8 and 5 respectively; the second part has 2 digits, 4 and 5 respectively.Calculate Digit Verification of CAS Registry Number 460085-45:
(8*4)+(7*6)+(6*0)+(5*0)+(4*8)+(3*5)+(2*4)+(1*5)=134
134 % 10 = 4
So 460085-45-4 is a valid CAS Registry Number.
InChI:InChI=1/C16H19NO10S.Na/c1-7-4-12(19)26-10-5-8(2-3-9(7)10)25-16-13(17-28(22,23)24)15(21)14(20)11(6-18)27-16;/h2-5,11,13-18,20-21H,6H2,1H3,(H,22,23,24);/q;+1/p-1/t11?,13-,14+,15+,16-;/m0./s1/rC16H18NNaO10S/c1-7-4-12(20)26-10-5-8(2-3-9(7)10)25-16-13(17-29(23,24)28-18)15(22)14(21)11(6-19)27-16/h2-5,11,13-17,19,21-22H,6H2,1H3/t11?,13-,14+,15+,16-/m0/s1
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4-Methylumbelliferyl 2-Sulfamino-2-deoxy-α-D-glucopyranoside Sodium Salt
