460086-95-7

Basic information

• Product Name: 1-(7-BROMOBENZOFURAN-2-YL)ETHANONE
• Synonyms: 2-Acetyl-7-bromobenzofuran
• CAS NO: 460086-95-7
• Molecular Formula: C₁₀H₇BrO₂
• Molecular Weight: 239.07
• Mol File: 460086-95-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(7-BROMOBENZOFURAN-2-YL)ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(7-BROMOBENZOFURAN-2-YL)ETHANONE(460086-95-7)
• EPA Substance Registry System: 1-(7-BROMOBENZOFURAN-2-YL)ETHANONE(460086-95-7)

Safety Data

• Hazardous Substances Data: 460086-95-7(Hazardous Substances Data)

Usage

General Description

1-(7-Bromobenzofuran-2-yl)ethanone is a chemical compound with the molecular formula C10H7BrO2. It is a derivative of benzofuran, a heterocyclic compound with a fused benzene and furan ring. The presence of the bromine atom at the 7-position of the benzofuran ring makes this compound a halogenated derivative, which can affect its reactivity and biological activity. The ethanone group at the 1-position of the benzofuran ring indicates the presence of a ketone functional group, which can participate in various chemical reactions. 1-(7-BROMOBENZOFURAN-2-YL)ETHANONE may have potential applications in synthetic organic chemistry, pharmaceuticals, and materials science due to its unique structure and reactivity.

Upstream product

• 1829-34-1 2-hydroxy-3-bromobenzaldehyde 
• 598-31-2 1-bromoacetone 
• 78-95-5 chloroacetone 

Downstream Products

• 460086-96-8 2-Acetyl-7-(2-propoxy-3-tert-butyl-5-ethylphenyl) benzo[b]furan 

Relevant articles and documents

Identification of novel STAT3 inhibitors bearing 2-acetyl-7-phenylamino benzofuran scaffold for antitumour study

Signal transducer and activator of transcription 3 (STAT3) is identified as a promising target for multiple cancer therapy and attracts widespread concern. Herein, we reported the discovery of a series of 2-acetyl-7-phenylamino benzofuran derivatives as STAT3 inhibitors using scaffold fusion strategy. Further structure activity relationship study led to the discovery of compound C6, which displayed the most potent anti-proliferation activities against MDA-MB-468 cells (IC50 = 0.16 μM). Western blot assay demonstrated that C6 inhibited the activation of STAT3 (Tyr705) without influencing the phosphorylation of STAT1 (Tyr701). Further mechanistic studies indicated that C6 caused a notable G2/M cycle-arresting and early apoptosis in a concentration-dependent manner in MDA-MB-468 cells. Finally, molecular modelling study elucidated the binding mode of C6 in STAT3 SH2 domain.

NEW ARYLALKENYLPROPARGYLAMINE DERIVATIVES EXHIBITING NEUROPROTECTIVE ACTION FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES

The invention relates to novel arylalkenylpropargylamine derivatives of general formula (I) or enantiomers or diastereomers thereof or salts, optionally pharmaceutically acceptable salts, or solvates of any of these. The compounds can be used in treating or preventing a disease or condition in a mammal related to monoamine oxidase dysfunction, especially in neurodegenerative diseases, e.g. Parkinson's disease, Alzheimer's disease or Huntington's disease.