460087-06-3

Upstream product

• 359-07-9 2-bromo-1,1-difluoroethane 
• 40020-87-9 2-acetyl-7-hydroxybenzofuran 
• 460086-97-9 trifluoro-methanesulfonic acid 2-acetyl-benzofuran-7-yl ester 
• 460088-02-2 3,5-diisopropyl-2-(2,2-difluoroethoxy) phenylboronic acid 
• 497-19-8 sodium carbonate 

Downstream Products

• 691888-40-1 2-fluoro-3-{7-[2-(2,2-difluoroethoxy)-3,5diisopropylphenyl]-benzo[b]furan-2-yl}-but-2-enoic acid ethyl ester 

Relevant academic research and scientific papers

Retinoid x receptor modulators

The present invention is directed to compounds represented by Structural Formula (I) and pharmaceutically acceptable salts, solvates and hydrates thereof: (I). The invention is also directed to pharmaceutical compositions, methods of use and methods of making compounds represented by Structural Formula (I) and pharmaceutically acceptable salts, solvates and hydrates thereof.

Design, synthesis and structure-activity relationship of novel RXR-selective modulators

The synthesis and in vitro characterization of novel RXR-selective ligands possessing various substituted 1-benzofuran or 1-benzothiophene moieties are described.