460087-63-2

Upstream product

• 330935-04-1 3,5-di-iso-propyl-2-(methoxymethoxy)benzene boronic acid 
• 460087-62-1 trifluoro-methanesulfonic acid 5-acetyl-benzo[b]thiophen-3-yl ester 
• 460087-61-0 5-Acetyl-benzo[b]thiophen-3-one 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 17067-15-1 (4-acetyl-phenylsulfanyl)-acetic acid 
• 92017-04-4 (4-acetyl-phenylsulfanyl)-acetic acid methyl ester 

Relevant academic research and scientific papers

Retinoid x receptor modulators

The present invention is directed to compounds represented by Structural Formula (I) and pharmaceutically acceptable salts, solvates and hydrates thereof: (I). The invention is also directed to pharmaceutical compositions, methods of use and methods of making compounds represented by Structural Formula (I) and pharmaceutically acceptable salts, solvates and hydrates thereof.

Design and synthesis of benzofused heterocyclic RXR modulators

Benzofused heterocyclic analogs of the RXR selective modulator 1 (LG101506) were synthesized, and tested for their ability to bind RXRα and activate RXR homo and heterodimers. Potency and efficacy were observed to be dependent upon the choice of heterocycle as well as the sidechain employed.