460346-03-6Relevant articles and documents
Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 2: Optimization of 5,8-disubstituted derivatives
, p. 4627 - 4631 (2004)
The optimization of 5,8-disubstituted spirocyclohexane-quinazolinones into potent, selective, soluble PDE7 inhibitors with acceptable in vivo pharmacokinetic parameters is presented.
Spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors
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, (2008/06/13)
The invention provides compounds which are PDE7inhibitors, having the following formula (I), (II) and (III) in which X1, X2, X3, X4, X, Y, Z, A and Z1 are as defined in the description, methods for pr