460346-07-0Relevant academic research and scientific papers
Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 2: Optimization of 5,8-disubstituted derivatives
Bernardelli, Patrick,Lorthiois, Edwige,Vergne, Fabrice,Oliveira, Chrystelle,Mafroud, Abdel-Kader,Proust, Emmanuelle,Pham, Nga,Ducrot, Pierre,Moreau, Fran?ois,Idrissi, Moulay,Tertre, Anita,Bertin, Bernadette,Coupe, Magali,Chevalier, Eric,Descours, Arnaud,Berlioz-Seux, Fran?oise,Berna, Patrick,Li, Mei
, p. 4627 - 4631 (2007/10/03)
The optimization of 5,8-disubstituted spirocyclohexane-quinazolinones into potent, selective, soluble PDE7 inhibitors with acceptable in vivo pharmacokinetic parameters is presented.
Spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors
-
, (2008/06/13)
The invention provides compounds which are PDE7inhibitors, having the following formula (I), (II) and (III) in which X1, X2, X3, X4, X, Y, Z, A and Z1 are as defined in the description, methods for pr
