460346-46-7Relevant academic research and scientific papers
Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 1
Lorthiois, Edwige,Bernardelli, Patrick,Vergne, Fabrice,Oliveira, Chrystelle,Mafroud, Abdel-Kader,Proust, Emmanuelle,Heuze, Lamia,Moreau, Fran?ois,Idrissi, Moulay,Tertre, Anita,Bertin, Bernadette,Coupe, Magali,Wrigglesworth, Roger,Descours, Arnaud,Soulard, Patricia,Berna, Patrick
, p. 4623 - 4626 (2007/10/03)
The synthesis and SAR studies of spiroquinazolinones as novel PDE7 inhibitors are discussed. The best compounds from the series displayed nanomolar inhibitory affinity and were selective versus other PDE isoenzymes.
