460365-22-4

Upstream product

• 460365-08-6 4-(4-cyanophenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester 
• 912556-70-8 tert-butyl 4-(4-cyanophenyl)-4-fluoropiperidine-1-carboxylate 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 3058-39-7 4-iodobenzonitrile 
• 871112-38-8 tert-butyl 4-(4-cyanophenyl)-4-hydroxypiperidine-1-carboxylate 
• 144397-70-6 4-(pyridin-4-yl)benzonitrile 

Downstream Products

• 437998-68-0 2-{4-[4-(4-cyano-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-butyrylamino}-benzamide 

Relevant academic research and scientific papers

B(C6F5)3-Catalyzed Cascade Reduction of Pyridines

B(C6F5)3 has been found to be an effective catalyst for reduction of pyridines and other electron-deficient N-heteroarenes with hydrosilanes (or hydroboranes) and amines as the reducing reagents. The success of this development hinges upon the realization of a cascade process of dearomative hydrosilylation (or hydroboration) and transfer hydrogenation. The broad functional-group tolerance (e.g. ketone, ester, unactivated olefins, nitro, nitrile, heterocycles, etc.) implies high practical utility.

NOVEL COMPOUNDS OF AMINO SULFONYL DERIVATIVES

The present invention relates to compounds with formula (I) or a pharmaceutically acceptable salt thereof: (I);wherein; T is a (4 to 10)-membered heterocyclyl and wherein R1, R2 and R3 are as defined in the specification. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and methods of treating a condition that is mediated by the modulation of the 11-β-hsd-1 enzyme.