46037-45-0

Usage

Chemical structure

A compound consisting of a cyclohexyl ring and a pyrrolidine ring attached to an amine group.

Form

Dihydrochloride salt, as indicated by the 2HCl in its name.

Usage

Commonly used as a synthetic intermediate in the production of pharmaceuticals, agrochemicals, and other organic compounds.

Application

Utilized as a reagent in various organic reactions, such as the formation of amides and carbamates.

Versatility

A valuable compound in the field of organic chemistry due to its ability to participate in a wide range of chemical reactions.

Biological activity

Used as an intermediate in the synthesis of biologically active molecules.

Upstream product

• 64-17-5 ethanol 
• 361535-68-4 2-Tetrahydro-1H-1-pyrrolylisoindolin-1,3-dione 
• 57796-60-8 6-chloro-5-ethylamino-3-methoxy-pyrazine-2-carboxylic acid 1-cyclohexyl-pyrrolidin-3-ylamide 

Downstream Products

• 65632-46-4 5-Chloro-N-(1-cyclohexyl-pyrrolidin-3-yl)-4-dimethylamino-2-methoxy-benzamide 
• 50733-98-7 N-(1-Cyclohexyl-3-pyrrolidinyl)-2-fluorobenzamide hydrochloride 
• 50734-46-8 N-(1-Cyclohexyl-3-pyrrolidinyl)-2-methoxy-5-sulfamoylbenzamide 
• 1226789-21-4 C₁₈H₂₃ClFN₃O₂ 
• 50733-97-6 3-bromo-N-(1-cyclohexyl-pyrrolidin-3-yl)-benzamide 

Relevant academic research and scientific papers

Discovery of 2-substituted 1H-benzo[d]immidazole-4-carboxamide derivatives as novel poly(ADP-ribose)polymerase-1 inhibitors with in?vivo anti-tumor activity

Novel 1H-benzo[d]immidazole-4-carboxamide derivatives bearing five-membered or six-membered N-heterocyclic moieties at the 2-position were designed and synthesized as PARP-1 inhibitors. Structure-activity relationships were conducted and led to a number of potent PARP-1 inhibitors having IC50 values in the single or double digit nanomolar level. Some potent PARP-1 inhibitors also had similar inhibitory activities against PARP-2. Among all the synthesized compounds, compound 10a and 11e displayed strong potentiation effects on temozolomide (TMZ) in MX-1?cells (PF50?=?7.10, PF50?=?4.17). In?vivo tumor growth inhibition was investigated using compound 10a in combination with TMZ, and it was demonstrated that compound 10a could strongly potentiate the cytotoxicity of TMZ in MX-1 xenograft tumor model. Two co-crystal structures of compounds 11b and 15e complexed with PARP-1 were achieved and demonstrated a unique binding mode of these benzo-imidazole derivatives.

NAPHTHALENYLOXYPROPENYL DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention discloses novel naphthalenyloxypropenyl derivatives useful for inhibiting the enzyme activity of histone deacetylase, leading effective suppression of cancer cell proliferation

ALKYLCARBAMOYL NAPHTHALENYLOXY- OCTENOYLHYDROXYAMIDE DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND PREPARATION THEREOF

This invention discloses a novel alkylcarbamoyl naphthalenyloxy octenoylhydroxyamide derivative of formula (1) useful for inhibiting the enzyme activity of histone deacetylase, which leads to effective suppression of the cancer cell proliferation, a method for preparing same and a pharmaceutical composition comprising same.

Pyrazine derivatives

Pyrazine derivatives by the formula STR1 are disclosed. In the above formula, R1 and R2, which may be the same or different, each represents a hydrogen atom, a halogen atom, a hydroxy group, a lower alkoxy group, a phenyl lower alkoxy group, a phenoxy group, a mercapto group, a lower alkylthio group, a phenyl lower alkylthio group, a phenylthio group, an amino group, a substituted amino group, a lower alkyl group, a carbamoyl group or a sulfamoyl group; R3 represents a lower alkoxy group; R4, R5, and R6, which may be the same or different, each represents a hydrogen atom, a lower alkyl group, a cycloalkyl group, a phenyl lower alkyl group, or a phenyl group; and A represents a lower alkylene group; said R4 and A, said R5 and A, said R4 and R5, or said R5 and R6 may form a 5-membered or 6-membered nitrogen-containing heterocyclic ring which may further contain a hetero-atom together with nitrogen atom, and the pharmacologically acceptable non-toxic salts thereof. The compounds of this invention have a strong and selective antiematic activity and an effect of stimulating the gastric motility.

N-Heterocyclic-9-xanthenylamines

The compounds are N-piperidinyl and pyrrolidinyl-9-xanthenylamines which are inhibitors of gastric acid secretion.