46045-65-2Relevant academic research and scientific papers
An assay for human telomeric G-quadruplex DNA binding drugs
Watkins, Derrick,Ranjan, Nihar,Kumar, Sunil,Gong, Changjun,Arya, Dev P.
, p. 6695 - 6699 (2013)
Compounds that stabilize the G-quadruplexes formed by human telomeres can inhibit the telomerase activity and are potential cancer therapies. We have developed an assay for the screening of compounds with high affinity for human telomeric G-quadruplexes (HTG). The assay uses a thiazole orange fluorescent reporter molecule conjugated to the aminoglycoside, neomycin, as a probe in a fluorescence displacement assay. The conjugation of the planar base stacking thiazole orange with the groove binding neomycin results in high affinity probe that can determine the relative binding affinity of high affinity HTG binding drugs in a high throughput format. The robust assay is applicable for the determination of the binding affinity of HTG in the presence of K+ or Na+.
Novel intercalating fluorescent dyes for labelling nucleic acids and the preparation method thereof
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Paragraph 0105-0107, (2021/03/30)
The novel intercalating fluorescent compounds of exemplary embodiments of the present invention for analyzing nucleic acids, etc. have excellent intercalating efficiency with nucleic acids such as DNA and RNA of biomaterials, and may not only continuously
Nucleic acid fluorescent dye as well as preparation and application thereof
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Paragraph 0058-0061, (2021/11/03)
The invention relates to the field of fluorescent dyes, in particular to a novel nucleic acid fluorescent dye. The invention provides a fluorescent dye, and the structural formula of the fluorescent dye is as shown in formula I, wherein A is chloride
COMPOUNDS, COMPLEXES, AND METHODS USEFUL FOR DETECTING AND/OR TREATING BACTERIAL PATHOGENS
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Paragraph 0055; 0200-0201; 0204-0205, (2020/08/30)
Compounds and complexes that can be useful as enterobactin probes not necessary are disclosed herein. Methods of detecting bacteria and/or methods of determining susceptibility of bacteria to an antibiotic using such compounds and complexes are also disclosed herein.
Fluorescence switchable probes based on a molecular rotor for selective detection of proteins and small molecules
Lai, Hsiu-Ping,Gao, Ruo-Cing,Huang, Chi-Ling,Chen, I-Chia,Tan, Kui-Thong
supporting information, p. 16197 - 16200 (2015/11/16)
In this communication, we report a general strategy to create fluorescence switchable probes, where a small molecule ligand is conjugated to a fluorescent molecular rotor, for the selective detection of proteins through a non-enzymatic process. In the presence of target proteins, bond rotation of the molecular rotor is restricted, thereby triggering the emission of strong fluorescence.
Design, synthesis and biological evaluation of new rhodacyanine analogues as potential antitumor agents
Li, Yang Xiong,Zhai, Xin,Liao, Wei Ke,Zhu, Wu Fu,He, Ying,Gong, Ping
scheme or table, p. 415 - 418 (2012/05/20)
In an attempt to develop potent antitumor agents, new rhodacyanine analogues containing the pyridinium ring (5a-5h), the isoquinolinium ring (6a-6c) and the quinolinium ring (7a-7e) linked to the rhodanine ring via N-N covalent bond were designed, synthesized and evaluated for antitumor activity against human lung cancer cell line (H460) by MTT assay in vitro. Most of the tested compounds showed enhanced antitumor activity with IC50 values ranging from 0.006 to 9.2 μmol/L as compared to the lead compound MKT-077. Among them, the most promising compound 7d (IC50 = 0.006 μmol/L) was 216.7 times more active than MKT-077 (IC50 = 1.3 μmol/L). The preliminary structure-activity relationship of the target compounds was discussed.
