46045-95-8

Upstream product

• 1706-11-2 2,5-Dimethyl-anisol 

Downstream Products

• 136917-73-2 1-(2-methoxy-4-methylphenyl)-2-(3-methoxy-4-methylphenyl)ethane 
• 136917-72-1 pseudo-m-4,13-dimethoxy<2.2>paracyclophane 
• 1242142-47-7 2-hydroxy-4-(bromomethyl)benzaldehyde 
• 863918-78-9 (E,E)-1-methoxy-2,5-bis(4-hydroxy)styrylbenzene 
• 1601462-12-7 (E,E)-1-methoxy-2,5-bis(4-hydroxymethyl)styrylbenzene 
• 1601462-13-8 (E,E)-1-methoxy-2,5-bis(4-trifluoromethyl)styrylbenzene 
• 1601462-14-9 (E,E)-1-methoxy-2,5-bis(4-trifluoromethoxy)styrylbenzene 
• 1601462-23-0 (E,E)-1-methoxy-2,5-bis(3-trifluoromethyl-4-methoxy)styrylbenzene 
• 1601462-40-1 C₃₇H₅₂O₃Si₂ 
• 906533-44-6 tetraethyl ((2-methoxy-1,4-phenylene)bis(methylene))bis(phosphonate) 

Relevant academic research and scientific papers

Bis-pyridylethenyl benzene as novel backbone for amyloid-β binding compounds

Detection of cerebral β-amyloid (Aβ) by targeted contrast agents is of great interest for in vivo diagnosis of Alzheimer's disease (AD). Partly because of their planar structure several bis-styrylbenzenes have been previously reported as potential Aβ imaging agents. However, these compounds are relatively hydrophobic, which likely limits their in vivo potential. Based on their structures, we hypothesized that less hydrophobic bis-pyridylethenylbenzenes may also label amyloid. We synthesized several bis-pyridylethenylbenzenes and tested whether these compounds indeed display improved solubility and lower Log?P values, and studied their fluorescent properties and Aβ binding characteristics. Bis-pyridylethenylbenzenes showed a clear affinity for Aβ plaques on both human and murine AD brain sections. Competitive binding experiments suggested a different binding site than Chrysamine G, a well-known stain for amyloid. With a Log?P value between 3 and 5, most bis-pyridylethenylbenzenes were able to enter the brain and label murine amyloid in vivo with the bis(4-pyridylethenyl)benzenes showing the most favorable characteristics. In conclusion, the presented results suggest that bis-pyridylethenylbenzene may serve as a novel backbone for amyloid imaging agents.

Efficient aqueous-processed hybrid solar cells from a polymer with a wide bandgap

In this work, MPPV with a wide bandgap is synthesized and combined with CdTe NCs for aqueous-processed polymer-nanocrystal hybrid solar cells (HSCs). A PCE of 5.18% is achieved, which is the highest for solar cells via an aqueous process. The function of

Polyfluorinated bis-styrylbenzenes as amyloid-β plaque binding ligands

Detection of cerebral β-amyloid (Aβ) by targeted contrast agents remains of great interest to aid the in vivo diagnosis of Alzheimer's disease (AD). Bis-styrylbenzenes have been previously reported as potential Aβ imaging agents. To further explore their potency as 19F MRI contrast agents we synthetized several novel fluorinated bis-styrylbenzenes and studied their fluorescent properties and amyloid-β binding characteristics. The compounds showed a high affinity for Aβ plaques on murine and human brain sections. Interestingly, competitive binding experiments demonstrated that they bound to a different binding site than chrysamine G. Despite their high logP values, many bis-styrylbenzenes were able to enter the brain and label murine amyloid in vivo. Unfortunately initial post-mortem 19F NMR studies showed that these compounds as yet do not warrant further MRI studies due to the reduction of the 19F signal in the environment of the brain.

Synthesis and characterization of an oligomeric conjugated metal-containing poly(p-phenylenevinylene) analogue

A new nickel-containing bis(bromobenzyl)salphen monomer suitable for Gilch polymerization was prepared. Reaction with KOtBu in THF-DMF afforded primarily gels, but also soluble, conjugated oligomers that are red-shifted in the absorption spectr

Thermodynamic forecasting of mechanically interlocked switches

Mechanically interlocked molecular (MIM) switches in the form of bistable [2]rotaxanes and [2]catenanes have proven to be - when incorporated in molecular electronic devices (MEDs) and in nanoelectromechanical systems (NEMS) - a realistic and viable alternative to the silicon chip density challenge. Structural modifications and chemical environment can have a large impact on the relaxation thermodynamics of the molecular motions, such as translation and circumrotation in bistable rotaxanes and catenanes responsible for the operation of devices based on MIMs. The effects of structural modifications on the difference in free energy (ΔGo) for the equilibrium processes in switchable MIMs can be predicted by considering, firstly, the interactions present in their precursor pseudorotaxanes. By employing isothermal titration microcalorimetry (ITC) to investigate the thermodynamic parameters governing pseudorotaxane formation for a series of monosubstituted, acceptor host cyclophanes with various donor guests, in conjunction with X-ray crystallographic data, an obvious link between the noncovalent bonding interactions in pseudorotaxanes and MIMs that survive following the formation of the mechanical bond can be identified. It follows that the changes (ΔΔGo values) in the difference of free energy during the formation of different pseudorotaxanes can subsequently be extrapolated to predict ΔGo values for the thermodynamics associated with switching in analogous MIM switches, employing the same donor-acceptor recognition components. In this manner, a systematic and predictive thermodynamic approach to designing and tuning switchable MIMs and MIM-based materials has been established. Additionally, these thermodynamic relationships are reminiscent of the long forgotten concept of the 'parachor' as a molecular descriptor with respect to the additivity of physical properties in chemical systems dealing specifically with quantitative structure property-activity relationships (QSPR/QSAR).

Derivatives of 1,4-bis(3-hydroxycarbonyl-4-hydroxyl)styrylbenzene as PTP1B inhibitors with hypoglycemic activity

Disalicylic acid derivatives with stilbene and bis-styrylbenzene skeleton were synthesized as PTP1B inhibitors. The most potent in this series exhibited a submicromolar IC50 value. One of the compounds 7b was tested in an animal model for its efficacy as an anti-diabetic or an anti-obesity agent. In feeding compound 7b to diet-induced obese mice, no significant differences in weight gain and food consumption were observed between the drug-treated and the obese control mice. However, 7b significantly lowered the fasting glucose level and improved the glucose tolerance in the obesity-induced diabetic mice.

Preparation and spectroscopic study of 13-substituted 2,11- dithiahexahydro[3.3]paracyclophanes

A series of 13-substituted 2,11-dithiahexahydro[3.3]paracyclophanes each containing a substituent on the benzene ring were prepared for 1H NMR and X-ray diffraction analyses. The benzene ring and the cyclohexane ring demonstrate shielding of th

New carbamoylpiperidines as human platelet aggregation inhibitors

A series of 3-carbamoylpiperidines (nipecotamides) are designed, synthesized and tested for their inhibitory action against adenosine diphosphate (ADP)-induced aggregation of human platelets. A structure- activity analysis of the bis(nipecotamido)aralkane type showed that a substituent on the piperidine ring should preferably be an amide and that the electronegativity of the carbonyl oxygen and the orientation of the amide group affected activities. Based on the knowledge of factors influencing platelet activation and aggregation, a nitric ester moiety which could release nitric oxide (NO) in situ, is incorporated into the nipecotamide structure. These compounds exhibit increased activity compared to those having no -ONO2 function. They also show stereoselectivity, with the meso isomer being approximately twice as potent as the synthetic diastereomeric mixture. Replacement of the -ONO2 function with hydroxyl, ester or alkyl groups considerably diminishes aggregation-inhibitory potential. Nipecotamides are shown here to inhibit the basal and collagen-induced rise in platelet inositol trisphosphate (IP3) levels, as well as phosphoinositide turnover. A comprehensive mechanism of action is proposed taking earlier results into consideration. (C) 2000 Elsevier Science Ltd.

Optical third harmonic generation of poly(2-alkoxy-1,4-phenylenevinylene)'s

A series of poly (2-alkoxy-1,4-phenylenevinylene)'s was synthesized by water-soluble precursor method. In this paper, three poly(1,4-phenylenevinylene) (PPV) derivatives were included, poly (2-methoxy-1,4-phenylenevinylene), poly(2-butoxy-1,4-phenylenevin