46052-84-0

Usage

Uses

Used in Chemical Industry:
2,5-Dichloroterephthalaldehyde is used as an intermediate in the synthesis of various organic compounds for its ability to form stable complexes with metal ions, which makes it useful in catalysis and as a reagent in organic synthesis.
Used in Materials Science:
In the field of materials science, 2,5-Dichloroterephthalaldehyde is used as a building block for the construction of novel polymers and advanced materials, leveraging its structural properties to create innovative materials with unique characteristics.
Used in Analytical Chemistry:
2,5-Dichloroterephthalaldehyde is used as a fluorescent probe for detecting certain ions in biological and environmental samples, capitalizing on its potential to emit fluorescence upon interaction with specific ions, thereby facilitating sensitive and selective detection methods.

InChI:InChI=1/C8H4Cl2O2/c9-7-1-5(3-11)8(10)2-6(7)4-12/h1-4H

Upstream product

• 41999-84-2 1,4-dichloro-2,5-bis-dichloromethyl-benzene 
• 681464-04-0 1,4-dichloro-2,5-bis(dibromomethyl)benzene 
• 95-72-7 2-chloro-1,4-dimethyl-benzene 
• 106-42-3 para-xylene 
• 1124-05-6 1,4-dichloro-2,5-dimethylbenzene 
• 7664-93-9 sulfuric acid 

Downstream Products

• 854633-26-4 2,5-bis-(toluene-4-sulfonylamino)-terephthalaldehyde 
• 85575-11-7 N,N'-bis<2-(dimethoxy)ethyl>-1,4-dichlorobenzene-1,4-bis(methanimine) 
• 235432-89-0 1,4-(CN(H)CH₂CH₂NMe₂)2-2,5-Cl₂C₆H₂ 
• 954149-19-0 2,5-Bis-phenylsulfanyl-benzene-1,4-dicarbaldehyde 
• 1445984-66-6 6-[(2,5-dichloro-4-[[(4R)-4-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]-1,3-thiazolidin-3-yl]methyl]phenyl)methoxy]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]pyridine-3-carboxamide 
• 1445984-68-8 5-[(2,5-dichloro-4-[[(4R)-4-[(4-cyclopropyl-1,2,3,4-tetrahydroquinoxalin-1-yl)carbonyl]-1,3-thiazolidin-3-yl]methyl]phenyl)methoxy]-N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl]pyridine-2-carboxamide 
• 1445986-02-6 (R)-4-(2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)benzyloxy)benzoic acid 
• 1445984-15-5 C₂₈H₂₉Cl₂N₅O₄S 

Relevant academic research and scientific papers

A Novel Strategy for the Construction of Covalent Organic Frameworks from Nonporous Covalent Organic Polymers

The field of covalent organic frameworks (COFs) has been developed significantly in the past decade on account of their important characteristics and vast application potential. On the other hand, the discovery of novel synthetic methodology is still a ch

Design of Gut-Restricted Thiazolidine Agonists of G Protein-Coupled Bile Acid Receptor 1 (GPBAR1, TGR5)

Bile acid signaling and metabolism in the gastrointestinal tract have wide-ranging influences on systemic disease. G protein-coupled bile acid receptor 1 (GPBAR1, TGR5) is one of the major effectors in bile acid sensing, with demonstrated influence on metabolic, inflammatory, and proliferative processes. The pharmacologic utility of TGR5 agonists has been limited by systemic target-related effects such as excessive gallbladder filling and blockade of gallbladder emptying. Gut-restricted TGR5 agonists, however, have the potential to avoid these side effects and consequently be developed into drugs with acceptable safety profiles. We describe the discovery and optimization of a series of gut-restricted TGR5 agonists that elicit a potent response in mice, with minimal gallbladder-related effects. The series includes 12 (TGR5 EC50: human, 143 nM; mouse, 1.2 nM), a compound with minimal systemic availability that may have therapeutic value to patients with type 2 diabetes mellitus, nonalcoholic steatohepatitis, or inflammatory bowel disease.

NON-SYSTEMIC TGR5 AGONISTS

Compounds of structure (I), or a stereoisomer, tautomer, pharmaceutically acceptable salt or prodrug thereof, wherein R1, R2, R3, R4, R8, R9, R10, R11, R12, A1, A2, X, Y and Z are as defined herein. Uses of such compounds as TGR5 antagonists and for treatment of various indications, including Type II diabetes meletus are also provided.