4607-38-9Relevant academic research and scientific papers
Evaluation of dalbavancin as chiral selector for HPLC and comparison with teicoplanin-based chiral stationary phases
Zhang, Xiaotong,Bao, Ye,Huang, Ke,Barnett-Rundlett, Kimber L.,Armstrong, Daniel W.
experimental part, p. 495 - 513 (2010/08/20)
Dalbavancin is a new compound of the macrocyclic glycopeptide family. It was covalently linked to 5 lm silica particles using two different binding chemistries. Approximately 250 racemates including (a) heterocyclic compounds, (b) chiral acids, (c) chiral amines, (d) chiral alcohols, (e) chiral sulfoxides and sulfilimines, (f) amino acids and amino acid derivatives, and (g) other chiral compounds were tested on the two new chiral stationary phases (CSPs) using three different mobile phases. As dalbavancin is structurally related to teicoplanin, the same set of chiral compounds was screened on two commercially available teicoplanin CSPs for comparison. The dalbavancin CSPs were able to separate some enantiomers that were not separated by the teicoplanin CSPs and also showed improved separations for many racemates. However, there were other compounds only separated or better separated on teicoplanin CSPs. Therefore, the dalbavancin CSPs are complementary to the teicoplanin CSPs.
Direct Optical Resolution of Carboxylic Acids by Chyral HPLC on Tris(3,5-dimethylphenylcarbamate)s of Cellulose and Amylose
Okamoto, Yoshio,Aburatani, Ryo,Kaida, Yuriko,Hatada, Koichi
, p. 1125 - 1128 (2007/10/02)
A variety of racemic carboxylic acids have been for the first time directly resolved by normal-phase, high-performance liquid chromatography using a hexane-2-propanol eluting system containing a small amount (ca. 1percent) of a strong carboxylic acid, like formic acid, trichloroacetic acid, and trifluoroacetic acid.
Preferential Cryatallization of 2-Amino-2-phenylethanol and Its Application as a Resolving Agent
Saigo, Kazuhiko,Miura, Hisao,Ishizaki, Kozi,Nohira, Hiroyuki
, p. 1188 - 1190 (2007/10/02)
(+/-)-2-Amino-2-phenylethanol (phenylglycinol) prepared from (+/-)-2-amino-2-phenylacetic acid (DL-phenylglycine) by lithium aluminium hydride reduction was efficiently resolved into a pair of optically active forms by preferential crystallization.The optically active amino alcohol was successfully applied as a basic resolving agent to the resolution of tartaric acid, 2-hydroxy-2-phenylpropionic acid, 2-hydroxy-3-phenylpropionic acid, 2-phenylpropionic acid, and 2-phenyl-2-ureidoacetic acid.
Optical Resolution of 2-Amino-1,2-diphenylethanol by Preferential Crystallization and Its Utilization in Fractional Crystallization and Enantioselective Reduction of Prochiral Ketones
Saigo, Kazuhiko,Ogawa, Shigeo,Kikuchi, Shigetoshi,Kasahara, Atsushi,Nohira, Hiroyuki
, p. 1568 - 1573 (2007/10/02)
(-/+)-erythro-2-Amino-1,2-diphenylethanol prepared from benzoin oxime by catalytic reduction was successfully resolved into pair of optically active forms by preferential crystallization.The optically active amino alcohol was found to be useful as a basic resolving agent for optical resolution of tartaric acid, trans-2,3-oxiranedicarboxylic acid, 2-hydroxy-2-phenylpropionic acid, and 3-endo-benzamido-5-norbornene-2-endo-carboxylic acid.Chiral hydrides prepared from lithium aluminium hydride and optical active threo- and erythro-2-amino-1,2-diphenylethanol derivatives were applied to the enantioface differentiating reduction of prochiral ketones to give the corresponding optically active alcohols in the 26-72percent optical purities.
