460990-23-2Relevant articles and documents
Efficient solid-phase synthesis of clavulones via sequential coupling of α- and ω-chains
Tanaka, Hiroshi,Hasegawa, Tsuyoshi,Iwashima, Makoto,Iguchi, Kazuo,Takahashi, Takashi
, p. 1103 - 1106 (2007/10/03)
We describe an efficient solid-phase synthesis of clavulones via the sequential coupling of the α- and ω-chains, involving two separate carbon - carbon bond-forming steps. The tetrahydropyranyl linker survived these reaction conditions and was cleaved without decomposing the unstable cross-conjugated dienones. Our methodology has allowed us to prepare six clavulone derivatives that are varied within the α-chain.