461-80-3Relevant academic research and scientific papers
Pyridine?BrF3, the missing link for clean fluorinations of aromatic derivatives
Hagooly, Youlia,Rozen, Shlomo
supporting information; experimental part, p. 1114 - 1117 (2012/04/10)
This work demonstrates the unique features of the never used before Py?BrF3 complex in the field of aromatic organic fluorinations. The main disadvantage of the noncomplexed BrF3 is the fact that usually, in addition to the desired fluorination, a parallel electrophilic aromatic bromination takes place as well. Use of the Py?BrF3 complex reduces this electrophilic bromination, which is observed with most reagents based on fluorine and bromine [BrF].
Preparation of alkyl and aryl chlorodifluoromethyl ethers using BrF 3
Hagooly, Youlia,Sasson, Revital,Welch, Michael J.,Rozen, Shlomo
experimental part, p. 2875 - 2880 (2009/04/07)
Both alkyl and aryl chlorothioformates could readily be obtained from the corresponding alcohols and thiophosgene. These families of compounds were treated with BrF3 to form the corresponding alkyl and aryl chlorodifluoromethyl ethers in 60-85% yields. The method is suitable for constructing a variety of aliphatic as well as electron-deficient aromatic chlorodifluoromethyl ethers. The reactions proceed under mild conditions and short reaction times. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
SYNTHESIS AND REACTIONS OF DIFLUOROMETHOXY- AND DIFLUOROCHLOROMETHOXY DERIVATIVES OF BENZENE
Shelyazhenko, S. V.,Fialkov, Yu. A.,Yagupol'skii, L. M.
, p. 1317 - 1324 (2007/10/02)
Difluoromethoxybenzaldehydes were synthesized by difluoromethylation of aromatic o- and p-hydroxyaldehydes by chladone-22 in alkaline medium.Chlorination of the difluoromethoxybenzene derivatives under illumination gave difluorochloromethoxy benzene with various function groups (F, Cl, CN, COCl, COOH).The values of the ?-constants of the OCF2Cl group have been determined.In its electronic characteristics it is similar to the OCF3 group.
