461-88-1 Usage
Chemical Properties
Light yellow Cryst
Uses
Different sources of media describe the Uses of 461-88-1 differently. You can refer to the following data:
1. 2,4-Pyridinediamine was studies for its interaction with cholinesterase inhibitors, neostigmine (N390010) and edrophonium (E336000) as a combined treatment for the restoration of muscle contraction. E
xperiments have shown the doses of neostigmine and edrophonium could be halved when they were combined with a small small amount of 2,4-pyridinediamine without apparent loss of antagonistic potency.
2. 2,4-Pyridinediamine was studies for its interaction with cholinesterase inhibitors, neostigmine (N390010) and edrophonium (E336000) as a combined treatment for the restoration of muscle contraction. Experiments have shown the doses of neostigmine and edrophonium could be halved when they were combined with a small small amount of 2,4-pyridinediamine without apparent loss of antagonistic potency.
Check Digit Verification of cas no
The CAS Registry Mumber 461-88-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,6 and 1 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 461-88:
(5*4)+(4*6)+(3*1)+(2*8)+(1*8)=71
71 % 10 = 1
So 461-88-1 is a valid CAS Registry Number.
InChI:InChI=1/C5H7N3/c6-4-1-2-8-5(7)3-4/h1-3H,(H4,6,7,8)
461-88-1Relevant articles and documents
2,4-Diamino-5-benzylpyrimidines and Analogues as Antibacterial Agents. 3. C-benzylation of Aminopyridines with Phenolic Mannich Bases. Synthesis of 1- and 3-Deaza Analogues of Trimethoprim.
Rauckman, Barbara S.,Roth, Barbara
, p. 384 - 391 (2007/10/02)
Electrophilic substitution of 2,4-diaminopyridine by 2,6-disubstituted-4-phenols and by halogens (bromine and fluorine) produces 3-benzyl and 3-halo derivatives, plus a small amount of disubstitution at the 3,5 positions.Treatment of a 2,4-diamino-3-halopyridine with phenolic Mannich bases gives 5- and N-benzylation. 2,4-Diamino-3-bromo-5-(4-hydroxy-3,5-dimethoxybenzyl)pyridine was methylated on the phenolic group in good yield and dehalogenated to produce 3-deazatrimethoprim .This compound is about 300-fold less active as an inhibitor of Escherichia coli dihydrof olate reductase than is trimethoprim. 2,6-Diaminopyridine is very readily dibenzylated at the 3,5 positions, as well as on an amino group, by a phenolic Mannich base; use of a fourfold excess of the pyridine provided a 3-benzylated 2,6-diaminopyridine in 50percent yield; this was inactive as an inhibitor of dihydrofolate reductase at 10-4 M. 2-Amino- and 4-aminopyridines do not produce C-benzylated products under the conditions reported here.
