461044-33-7

Upstream product

• 461044-28-0 Methanesulfonic acid (R)-2-[(4R,5S)-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-pent-4-enyl ester 
• 461044-26-8 (S)-2-[(4R,5S)-2-(4-Methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-pent-4-enoic acid methyl ester 
• 461044-27-9 (R)-2-[(4R,5S)-2-(4-Methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-pent-4-en-1-ol 
• 473251-43-3 (4S,5S)-5-Methyl-tetrahydro-pyran-2,4-diol 
• 461044-22-4 (4S,5S)-4-Hydroxy-5-methyl-tetrahydro-pyran-2-one 
• 2186-92-7 p-Anisaldehyde dimethyl acetal 
• 461044-32-6 (5S,6S,7S,8S)-5-Hydroxy-7-(4-methoxy-benzyloxy)-4,4,6,8-tetramethyl-3-oxo-undec-10-enoic acid tert-butyl ester 
• 461044-31-5 (2R,3S,4S)-3-(4-Methoxy-benzyloxy)-2,4-dimethyl-hept-6-enal 
• 461044-29-1 (4S,5S)-2-(4-Methoxy-phenyl)-5-methyl-4-((S)-1-methyl-but-3-enyl)-[1,3]dioxane 
• 461044-25-7 (S)-2-((1R,2S)-1,3-Dihydroxy-2-methyl-propyl)-pent-4-enoic acid methyl ester 
• 461044-23-5 (3S,4R,5S)-3-Allyl-4-hydroxy-5-methyl-tetrahydro-pyran-2-one 

Downstream Products

• 461044-45-1 (Z)-(4S,7R,8S,9S,16S)-4-(tert-Butyl-dimethyl-silanyloxy)-8-(4-methoxy-benzyloxy)-5,5,7,9-tetramethyl-16-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-oxacyclohexadec-13-ene-2,6-dione 
• 461044-35-9 3-(tert-butyl-dimethyl-silanyloxy)-7-(4-methoxy-benzyloxy)-4,4,6,8-tetramethyl-5-oxo-undec-10-enoic acid tert-butyl ester 
• 186692-73-9 desoxyepothilone A 
• 152044-53-6 epithilone A 
• 461044-34-8 (3S,5S,6S,7S,8S)-3-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-7-(4-methoxy-benzyloxy)-4,4,6,8-tetramethyl-undec-10-enoic acid tert-butyl ester 

Relevant academic research and scientific papers

Aldolase-catalyzed asymmetric synthesis of novel pyranose synthons as a new entry to heterocycles and epothilones

Enzymatic reactions catalyzed by DERA provide the basis for a new strategy for the synthesis of novel pyranose synthons. The utility of this very convergent and effective method is demonstrated by the concise total synthesis of epothilones (see scheme; DERA = 2-deoxyribose-5-phosphate aldolase).