461391-24-2 Usage
Uses
Used in Research and Development:
4-PHENYLBUTYRIC-2,2,3,3-D4 ACID is used as a research compound for studying the properties and behavior of its non-deuterated counterpart, 4-phenylbutyric acid, in various chemical and biological processes. The deuterium labeling allows for enhanced detection and tracking of the compound in experiments, providing valuable insights into its interactions and mechanisms of action.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-PHENYLBUTYRIC-2,2,3,3-D4 ACID is used as a starting material or intermediate in the synthesis of various drugs and drug candidates. Its isotopically labeled nature can be advantageous for studying the metabolic pathways and pharmacokinetics of related compounds, potentially leading to the development of more effective and safer medications.
Used in Chemical Industry:
4-PHENYLBUTYRIC-2,2,3,3-D4 ACID is also used in the chemical industry for the synthesis of various specialty chemicals, such as deuterated analogs of pharmaceuticals, agrochemicals, and other industrial chemicals. The deuterium labeling can provide unique properties and advantages for these applications, such as improved stability or altered reactivity.
Used in Analytical Chemistry:
4-PHENYLBUTYRIC-2,2,3,3-D4 ACID is employed as a reference material or internal standard in analytical chemistry, particularly in techniques such as mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy. The deuterium labeling can improve the accuracy and precision of these measurements, enabling more reliable identification and quantification of target compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 461391-24-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,6,1,3,9 and 1 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 461391-24:
(8*4)+(7*6)+(6*1)+(5*3)+(4*9)+(3*1)+(2*2)+(1*4)=142
142 % 10 = 2
So 461391-24-2 is a valid CAS Registry Number.
461391-24-2Relevant academic research and scientific papers
SUBSTITUTED ETHANOLAMINES
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Page/Page column 24, (2010/02/17)
The present invention relates to new substituted ethanolamine adrenergic receptor modulators, pharmaceutical compositions thereof, and methods of use thereof.
H/D-exchange reactions with hydride-activated catalysts
Derdau, Volker,Atzrodt, Jens,Holla, Wolfgang
, p. 295 - 299 (2008/02/08)
A safe, user friendly and efficient method to provide high deuterium incorporation into a variety of organic substrates was developed. Systematic screening of catalysts and activators revealed that the activation of the Pd- or Rh-catalyst by NaBD4 is essential for the H/D exchange. The feasibility has been demonstrated by the successful application of this method to bi- and tricyclic aromatic compounds as well as chiral natural products like dextrorphan or drugs like formoterol. Copyright
Exposure to a deuterated analogue of phenylbutyrate retards S-phase progression in HT-29 colon cancer cells
Clarke, Kevin O.,Ludeman, Susan M.,Springer, James B.,Michael Colvin,Lea, Michael A.,Harrison, Lawrence E.
, p. 1054 - 1064 (2007/10/03)
Differentiation agents that induce neoplastic cells to regain a normal phenotype and/or cause growth arrest without significantly affecting normal cells represent an attractive option for cancer treatment. Analogues of short chain fatty acids, such as phe
