4614-03-3Relevant academic research and scientific papers
Stereospecific nickel-catalyzed cross-coupling reactions of alkyl ethers: Enantioselective synthesis of diarylethanes
Taylor, Buck L. H.,Swift, Elizabeth C.,Waetzig, Joshua D.,Jarvo, Elizabeth R.
supporting information; experimental part, p. 389 - 391 (2011/04/16)
Secondary benzylic ethers undergo stereospecific substitution reactions with Grignard reagents in the presence of nickel catalysts. Reactions proceed with inversion of configuration and high stereochemical fidelity. This reaction allows for facile enantio
Kumada coupling of aryl and vinyl tosylates under mild conditions
Limmert, Michael E.,Roy, Amy H.,Hartwig, John F.
, p. 9364 - 9370 (2007/10/03)
Aryl and alkenyl tosylates are easily prepared, inexpensive and, thus, attractive for transition-metal-catalyzed couplings, but their reactivity is low. We report examples of mild, palladium-catalyzed coupling of aryl, alkenyl, and alkyl Grignard reagents with aryl and alkenyl tosylates. The resulting biaryls, vinylarenes, and alkylarenes were isolated in good to excellent yield. These couplings were conducted with a nearly equimolar ratio of the two reactants, and many examples were conducted at room temperature.
