461424-18-0

Basic information

• Product Name: 7-fluoro-1-(2-fluoro-phenyl)-9H-β-carboline
• CAS NO: 461424-18-0
• Molecular Weight: 280.277
• Mol File: 461424-18-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-fluoro-1-(2-fluoro-phenyl)-9H-β-carboline(CAS DataBase Reference)
• NIST Chemistry Reference: 7-fluoro-1-(2-fluoro-phenyl)-9H-β-carboline(461424-18-0)
• EPA Substance Registry System: 7-fluoro-1-(2-fluoro-phenyl)-9H-β-carboline(461424-18-0)

Safety Data

• Hazardous Substances Data: 461424-18-0(Hazardous Substances Data)

Upstream product

• 7730-20-3 DL-6-fluorotryptophan 
• 446-52-6 2-Fluorobenzaldehyde 

Relevant articles and documents

β-Carbolines as specific inhibitors of cyclin-dependent kinases

Harmine (3), 7-fluoro-1-methyl β-carboline (35) and 1-(5-methyl-imidazol-4-yl) β-carboline (41) were potent and specific inhibitors of cyclin-dependent kinases. The degree of aromaticity of the tricyclic ring and the positioning of substituents are important for inhibitory activity. While most β-carbolines inhibited CDK2 and CDK5 to the same extent, selective inhibition against CDK2 was observed in 1-(2-chlorophenyl)- (12), 1-(2-fluorophenyl)- (15), and 1-(2-chloro-5-nitrophenyl)- (28) β-carbolines.