461433-06-7

Upstream product

• 138458-70-5 1,2,5-triphenylphospholane oxide 
• 870-63-3 prenyl bromide 

Downstream Products

• 461433-26-1 (1R,2S,5S)-2-[2-(benzylamino)ethyl]-1,2,5-triphenylphospholane-1-oxide 
• 461433-25-0 (1R,2S,5S)-2-(diethylaminoethyl)-1,2,5-triphenylphospholane-1-oxide 
• 461433-23-8 (1R,2S,5S)-2-(2'-hydroxyethyl)-1,2,5-triphenylphospholane-1-oxide 
• 461433-22-7 (1R,2S,5S)-2-(2'-oxoethyl)-1,2,5-triphenylphospholane-1-oxide 

Relevant academic research and scientific papers

Enantioselective synthesis of phospholanes using chiral lithium amide desymmetrisation

The enantioselective deprotonation of 1,2,5-triphenylphospholane oxide with a chiral base, followed by electrophilic quenching, gives a range of chiral products in good yield and in ca. 85% ee. The absolute and relative configuration of two of the products was determined by X-ray crystallography. A number of the chiral phospholane oxides were subjected to further transformations, in particular reduction to give enantiomerically pure phospholanes.