461639-19-0Relevant articles and documents
Preparation of 1,5-disubstituted pyrrolidin-2-ones
Katritzky, Alan R.,Mehta, Shamal,He, Hai-Ying,Cui, Xilin
, p. 4364 - 4369 (2000)
1,5-Disubstituted pyrrolidin-2-ones 18a-g, 19a-h, and 20a-f were synthesized in good to excellent yields via the nucleophilic substitution of 5-(benzotriazol-1-yl)-1-substituted-pyrrolidin-2-ones 9 with allylsilanes, organozinc reagents, and phosphorus compounds. Compounds 9 and 5- (benzotriazol-2-yl)-1-substituted-pyrrolidin-2-one isomers 10 are readily prepared in total 70-84% yields from 2,5-dimethoxy-2,5-dihydrofuran(7), primary amines 8, and benzotriazole; 9 and 10 react identically with nucleophiles.