461663-38-7

Upstream product

• 994-30-9 triethylsilyl chloride 
• 59697-71-1 ethyl 6-methyl-3-oxohept-6-enoate 
• 72272-31-2 2,5-dimethylcyclohept-4-en-1-one 
• 461663-55-8 ethyl 2-allyl-6-methyl-3-oxo-6-heptenoate 
• 461663-24-1 2,6-dimethylnona-1,8-dien-5-one 
• 461663-23-0 ethyl 1,4-dimethyl-7-oxo-3-cycloheptenecarboxylate 
• 461663-37-6 methyl (1S)-3-(1,4-dimethyl-7-oxocyclohept-3-enyl)propanoate 
• 461663-22-9 ethyl 2-allyl-2,6-dimethyl-3-oxo-6-heptenoate 
• 461663-26-3 ethyl 2-allyl-2,6-dimethyl-3-hydroxy-6-heptenoate 
• 461663-29-6 1,4-dimethyl-7-triethylsilyloxy-3-cycloheptenecarboxylate 
• 461663-27-4 ethyl 2-allyl-2,6-dimethyl-3-triethylsilyloxy-6-heptenoate 

Relevant academic research and scientific papers

Total synthesis and absolute configuration of liverwort diterpenes, (-)-13(15)E,16E-3β,4β-epoxy-18-hydroxysphenoloba-13(15),16-diene and (-)-13(15)Z,16E-3β,4β-epoxy-18-hydroxysphenoloba-13(15), 16-diene, by use of the ring closing metathesis reaction applied to seven-membered carbocycles with a trisubstituted double bond

Seven-membered cyclic compounds possessing trisubstituted double bonds have been effectively constructed employing the Grubbs catalyst to effect olefin metathesis. The keto ester does not undergo cyclization; however, alcohols protected by the silyl groups smoothly cyclized into sevenmembered compounds. The product was successfully converted to (-)-13(15)E,16E-3β,4β-epoxy18-hydroxysphenoloba-13(15),16-diene and (-)-13(15)Z,16E-3β,4β-epoxy-18-hydroxysphenoloba13(15),16-diene, liverwort diterpenes isolated from Anastrophyllum auritum to establish the absolute configuration.