461664-22-2Relevant academic research and scientific papers
Total synthesis of the amaryllidaceae alkaloid (+)-plicamine and its unnatural enantiomer by using solid-supported reagents and scavengers in a multistep sequence of reactions
Baxendale, Ian R.,Ley, Steven V.,Piutti, Claudia
, p. 2194 - 2197 (2007/10/03)
A sequence of polymer-supported reagents and scavengers was used to promote the synthetic transformations in the first total synthesis of (+)-plicamine (1), a member of the amaryllidaceae alkaloid family, starting from L-4-hydroxyphenylglycine (see scheme).
Total synthesis of the amaryllidaceae alkaloid (+)-plicamine using solid-supported reagents
Baxendale, Ian R,Ley, Steven V,Nessi, Marcella,Piutti, Claudia
, p. 6285 - 6304 (2007/10/03)
In this report we describe in full the total synthesis of the amaryllidaceae alkaloid (+)-plicamine 1 including a model compound study. In both cases the compounds were prepared using solid-supported reagents and scavengers in multi-step sequences of reactions to give materials which required no conventional purification but could be carried on to the next synthetic step.
