461665-22-5Relevant academic research and scientific papers
α,β-Cyclic-β-benzamido hydroxamic acids: Novel oxaspiro[4.4]nonane templates for the discovery of potent, selective, orally bioavailable inhibitors of tumor necrosis factor-α converting enzyme (TACE)
Ott, Gregory R.,Asakawa, Naoyuki,Liu, Rui-Qin,Covington, Maryanne B.,Qian, Mingxin,Vaddi, Krishna,Newton, Robert C.,Trzaskos, James M.,Christ, David D.,Galya, Laurine,Scholz, Thomas,Marshall, Will,Duan, James J.-W.
, p. 1288 - 1292 (2008/09/19)
Two novel oxaspiro[4.4]nonane β-benzamido hydroxamic scaffolds have been synthesized in enantio- and diasteriomerically pure form. These templates proved to be exceptional platforms that have led to the discovery of potent inhibitors of TACE that are acti
