461665-65-6

Upstream product

• 2417-72-3 Methyl 4-(bromomethyl)benzoate 
• 123-54-6 acetylacetone 
• 461665-64-5 methyl 4-[(3,5-dimethyl-1H-pyrazol-4-yl)methyl]-benzoate 
• 26496-94-6 Ethyl 4-(bromomethyl)benzoate 

Downstream Products

• 477582-04-0 (cis,trans)-4-[(3,5-dimethyl-1H-pyrazol-4-yl)methyl]-N-(2,4-dioxo-7-oxa-1,3-diazaspiro[4.5]dec-10-yl)benzamide 

Relevant academic research and scientific papers

Exploiting the pyrazole-carboxylate mixed ligand system in the crystal engineering of coordination polymers

The utility of the pyrazole-carboxylate mixed ligand system has been probed with the synthesis of five new coordination polymers, derived from bis-pyrazole ligand 4,4′-methylenebis(3,5-dimethyl-1H-pyrazole) H2L1, large semirigid dicarboxylate coligands, and the deliberately designed and synthesized ligand para-((3,5-dimethyl-1H-pyrazol-4-yl)-methylene)benzoic acid H2L4. Complex poly-[Co(H2L1)-(L2)(OH2)]·1/2H2O 1 features the coligand (S,S)-1,4,5,8-naphthalenetetracarboxylic diimide-N,N′-bis(2-propionate) L2, and comprises chiral two-dimensional sheets, associating via substantial π-π stacking interactions. Complexes 2 and 3 contain the coligand 1,4-bis((3-carboxyphenyl)methyl)-piperazine L3. Complex poly-[Co(H2L1)2(L3)] 2 is a two-dimensional polymer containing octahedral Co(II) ions, whereas modifying the synthesis conditions gave complex poly-[Co2(HL1)2(L3)] 3, a three-dimensional α-Po structure containing pyrazolate-bridged dimers of tetrahedral Co(II) ions, displaying weak antiferromagnetic coupling. Magnetic data for complex 3 fitted well to a S = 3/2 Heisenberg (-2JS1.S2) dimer model with J = -3.2 cm-1 and g = 2.25. We then prepared the new heteroditopic ligand para-((3,5-dimethyl-1H-pyrazol-4-yl)methylene)-benzoic acid H2L4, and the complexes poly-[Co(HL4)2]·H2O 4 and poly-[Cu(HL4)2]·2MeOH 5, which demonstrate for the first time the tendency of flexible pyrazole-carboxylate coordination polymers with perfectly commensurate linker dimensions to lead to low-dimensional assemblies. These results give fresh insight into the structural properties of flexible bispyrazole-carboxylic acid systems as a function of coligand dimensions, and provide new directions for designed polymeric cluster compounds.

A metal-organic framework with rod secondary building unit based on the Boerdijk-Coxeter helix

The renowned aperiodic Boerdijk-Coxeter helix is identified, with a modified, periodic form, in a MOF named ROD-1 [formulated as Cd(L), H2L = (3,5-dimethyl-1H-(pyrazol-4-yl)-methylene)benzoic acid], which exhibits unusual gas adsorption behavio

Hydantoins and related heterocycles as inhibitors of matrix metalloproteinases and/or TNF-alpha converting enzyme (TACE)

The present application describes novel hydantoin derivatives of formula (I): or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, R1, R2, R3, R4, R5, R6, R7, R11, and n are defined in the present specification, which are useful as inhibitors of matrix metalloproteinases (MMP), TNF-α converting enzyme (TACE), aggrecanase, or a combination thereof.