46176-91-4

Upstream product

• 66938-35-0 (4-fluor-3-nitrophenyl)-cyclopropylmethanon 
• 772-31-6 cyclopropyl(4-fluorophenyl)methanone 
• 31431-23-9 cyclopropyl (4-amino-3-nitrophenyl)methanone 

Relevant academic research and scientific papers

Synthesis and anthelminthic acitivity of alkyl-(5-acyl-1-benzimidazol-2-yl) carbamates

A series of alkyl-(5-acyl-l-H-benzimidazol-2-yl)-carbamates were prepared and screened for anthelminthic activity. Some of them were found to be fully active at low, atoxic oral dose levels against gastro-intestinal nematodes. The activity against Syphacia muris and Strongyloides ratta is indicated. From these studies methyl (5-benzoyl-1-H-benzimidazol-2-yl) carbamate (mebendazole) and methyl [5-(4-fluorobenzoyl)-1-H-benzimidazol-2-yl]carbamate (flubendazole) were selected for detailed investigation.