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4619-09-4

Phosphoric acid, m-(dimethylamino)phenyl diethyl ester, also known as dimethylamino diethyl ester of phosphoric acid, is a complex organic compound with the chemical formula C12H22NO3P. It is a colorless to pale yellow liquid with a molecular weight of 265.29 g/mol. This ester is derived from phosphoric acid and features a dimethylamino group attached to a phenyl ring, with two diethyl ester groups bonded to the phosphorus atom. It is synthesized through the reaction of phosphoric acid with m-(dimethylamino)phenol and diethyl phosphite. Phosphoric acid, m-(dimethylamino)phenyl diethyl ester is used as a flame retardant, particularly in the production of intumescent coatings and plastics, due to its ability to char and form a protective layer when exposed to heat. It is also known for its potential applications in the synthesis of various pharmaceuticals and agrochemicals.

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  • 4619-09-4 Structure

  • Basic information

    1. Product Name: Phosphoric acid, m-(dimethylamino)phenyl diethyl ester
    2. Synonyms:
    3. CAS NO:4619-09-4
    4. Molecular Formula:
    5. Molecular Weight: 273.269
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 4619-09-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Phosphoric acid, m-(dimethylamino)phenyl diethyl ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: Phosphoric acid, m-(dimethylamino)phenyl diethyl ester(4619-09-4)
    11. EPA Substance Registry System: Phosphoric acid, m-(dimethylamino)phenyl diethyl ester(4619-09-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 4619-09-4(Hazardous Substances Data)

4619-09-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4619-09-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,6,1 and 9 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 4619-09:
(6*4)+(5*6)+(4*1)+(3*9)+(2*0)+(1*9)=94
94 % 10 = 4
So 4619-09-4 is a valid CAS Registry Number.

4619-09-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name [3-(dimethylamino)phenyl] diethyl phosphate

1.2 Other means of identification

Product number -
Other names Phosphorsaeure-<O,O-diaethylester>-<O-3-dimethylamino-phenylester>

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:4619-09-4 SDS

4619-09-4Relevant articles and documents

Inhibition of cholinesterases with cationic phosphonyl oximes highlights distinctive properties of the charged pyridine groups of quaternary oxime reactivators

Ashani, Yacov,Bhattacharjee, Apurba K.,Leader, Haim,Saxena, Ashima,Doctor, Bhupendra P.

, p. 191 - 202 (2007/10/03)

Oxime-induced reactivation of phosphonylated cholinesterases (ChEs) produces charged phosphonyl pyridine oxime intermediates (POXs) that are most potent organophosphate (OP) inhibitors of ChEs. To understand the role of cationic pyridine oxime leaving groups in the enhanced anti-ChE activity of POXs, the bimolecular rate constants for the inhibition (ki) of acetylcholinesterases (AChE) and butyrylcholinesterases (BChE), and the rate of decomposition (kd) of authentic O-alkyl methylphosphonyl pyridine oximes (AlkMeP-POXs) and N,N-dimethylamidophosphoryl pyridine oximes (EDMP-POXs), were studied. Stability ranking order in aqueous solutions correlated well with the electronic features and optimized geometries that were obtained by ab initio calculations at 6-31G** basis set level. AlkMeP-POXs of the 2-pyridine oxime series were found to be 4- to 8-fold more stable (t1/2=0.7 to 1.5min) than the homologous O,O-diethylphosphoryl (DEP) oxime. Results suggest that re-inhibition of enzyme activity by POX is less likely during the reactivation of DEP-ChEs (obtained by use of DEP-containing pesticides) by certain oximes, compared to nerve agent-inhibited ChEs. The greatest inhibition was observed for the O-cyclohexyl methylphosphonyl-2PAM derivative (4.0×109M-1min-1; mouse AChE) and is 10-fold higher than the ki of cyclosarin. Increasing the size of the O-alkyl substituent of AlkMeP-POXs had only a small to moderate effect on the ki of ChEs, signifying a major role for the cationic pyridine oxime leaving group in the inhibition reaction. The shape of plots of log ki vs. pKa of the leaving groups for AlkMeP-PAMs and DEP-PAMs, could be used as a diagnostic tool to highlight and rationalize the unique properties of the cationic moiety of pyridine oxime reactivators.

A convenient method for the phosphorylation of phenols with diethyl cyanophosphonate

Guzman, Angel,Diaz, Eduardo

, p. 3035 - 3038 (2007/10/03)

Phosphorylation of phenols with diethyl cyanophosphonate in methylene chloride solution at 0°C is an easy, rapid and good yielding reaction.

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