462-12-4Relevant academic research and scientific papers
Synthesis of ω-fluorinated octanoic acid and its β-substituted derivatives
Nagatsuki, Fumi,Sasaki, Shigeki,Maeda, Minoru
, p. 373 - 383 (2007/10/02)
Simple syntheses are described for the ω-fluorinated analogs of octanoic acid and its β-substituted derivatives in which insertion of a methyl and dimethyl group, and oxygen substitution at the C-3 position are involved, employing nucleophilic displacement with fluoride ion of the tosylate functions in the later stage of synthesis.The synthetic procedures offer easy and convenient acces to the corresponding 18F-labeled analogs using the readily available fluoride ion.
