462101-85-5Relevant academic research and scientific papers
One pot syntheses of thiazol-2-hydrazone, pyridino[2,3-d]pyridazine, pyrazolo[3,4-d]pyridazine, and isoxazolo[4,5-d]pyridazine derivatives
Mohareb, Rafat M.,Fleita, Daisy H.
, p. 258 - 262 (2002)
The synthesis of the heterocyclic compounds containing two rings through the use of 4-amino-5-cyano-6-oxo-1-arylpyridazine-3-hydrazidic acid derivatives was discussed. Compounds containing both the pyridazine and thiazole moieties was found to possess potential biological activities. The reactivity of 4-amino-5-cyano-6-oxo-1-phenyl-3-carbohydrazido-N-(3-phenyl-4-oxothiazolidi -n-2-ylidino)-pyridazine (6a) was discussed. The reactivity of the enaminonitrile moiety present in (6a) towards some chemical reagents was studied. The reactions of (6a) with malononitrile and ethylcyanoacetate were studied in order to acvhieve the synthesis of fused azinoazine derivatives incorporating high biological activities.
