462122-84-5Relevant academic research and scientific papers
Influence of acid surrogates toward potency of VLA-4 antagonist
Venkatraman, Shankar,Lim, Jongwon,Cramer, Merryl,Gardner, Michael F.,James, Joyce,Alves, Kenneth,Lingham, Russell B.,Mumford, Richard A.,Munoz, Benito
, p. 4053 - 4056 (2007/10/03)
A series of VLA-4 antagonist were synthesized wherein carboxylic acid was replaced by various acid surrogates. The effect of these acid surrogates toward potency was evaluated in a binding assay. A number of acid surrogates were potent antagonist of VLA-4
