46237-45-0Relevant academic research and scientific papers
A KINETIC STUDY OF PHOSPHINIC CARBOXYLIC MIXED ANHYDRIDES
Ramage, Robert,Atrash, Butrus,Hopton, David,Parrott, Maxwell J.
, p. 1617 - 1622 (2007/10/02)
Using 32.4 MHz (31)P n.m.r. spectroscopy, disproportionation of a series of phosphinic carboxylic mixed anhydrides derived from protected α-amino acids has been studied both as a function of the substituents at phosphorus and structure of the α-amino acid being activated.It was found that the rates of disproportionation were insignificant from a preparative aspect compared with aminolysis at 0 deg C.
A NEW REAGENT FOR THE MEDIATION OF AMIDE BOND FORMATION IN PEPTIDE SYNTHESIS.
Ramage, Robert,Ashton, Christopher P.,Hopton, David,Parrott, Maxwell J.
, p. 4825 - 4828 (2007/10/02)
The potential application of 1-oxo-1-chlorophospholane (5) as a novel reagent for the in situ activation of N α-protected amino acids for use in peptide bond forming reactions has been examined.Wherever possible, 32.4 MHz 31P nuclear magnetic resonance (n.m.r.) spectroscopy was employed to follow both the formation of the intermediate phospholanic-carboxylic mixed anhydride and the subsequent aminolysis reaction.
