4626-22-6Relevant academic research and scientific papers
Induction of targeted osteogenesis with 3-aryl-2H-benzopyrans and 3-aryl-3H-benzopyrans: Novel osteogenic agents
Gupta, Atul,Ahmad, Imran,Kureel, Jyoti,Hasanain, Mohammad,Pandey, Praveen,Singh, Sarita,John, Aijaz A.,Sarkar, Jayanta,Singh, Divya
, p. 63 - 75 (2016/03/19)
Development of target oriented chemotherapeutics for treatment of chronic diseases have been considered as an important approach in drug development. Following this approach, in our efforts for exploration of new osteogenic leads, substituted 3-aryl-2H-be
Synthesis and anti-tumor activities of novel oxazinyl isoflavonoids
Wang, Dun,Hou, Like,Wu, Lirong,Yu, Xin
, p. 513 - 520 (2012/05/05)
The design, synthesis and biological evaluation of a novel series of oxazinyl isoflavonoids is described. Several analogs were shown to exhibit growth inhibitory effects against SKOV-3, DU-145 and HL-60 human colon cancer cell lines with IC50 values in the micromolar range. The cellular potency of compounds 7e and 12h were found to have greater in vitro inhibitory activities than phenoxodiol, the parental compound currently in late-stage clinical trials for the treatment of cancer. The results shown are suitable for further lead optimization.
HYDROGEN TRANSFER REDUCTION OF ISOFLAVONES
Waehaelae, K.,Hase, T. A.
, p. 183 - 186 (2007/10/02)
Hydrogen transfer reduction of isoflavones using ammonium formate and palladium charcoal provides an easy access to polyoxyisoflavanones and also to isoflavan-4-ols without the need for protection of the hydroxy groups.Optimized reaction conditions for im
A New General Synthesis of Hydroxy- and Methoxy-isoflavones
Jain, Amolak C.,Mehta, Anita
, p. 215 - 220 (2007/10/02)
A new general synthesis of hydroxy- (5e-h) and methoxy- (5e-d) isoflavones has been accomplished in overall yields of 47-73percent from the corresponding 2-hydroxydeoxybenzoins (1a-h).The first step involves reaction with appropriate amounts of ethoxymeth
A New General Synthesis of Polyhydroxyisoflavanones
Jain, Amolak C.,Sharma, Anita
, p. 338 - 339 (2007/10/02)
Hydroxyisoflavanones have been conveniently synthesised from hydroxydesoxybenzoins in 47-57 percent overall yields in four steps which could be carried out either continuously or by isolating the products at each stage.
Some Photochemical and Oxidative Conversions of Pterocarpans and Isoflavans: Functional Requirements for Cyclization of Isoflavans to Pterocarpans
Breytenbach, Jaco C.,Zyl, Jan J. van,Merwe, Pieter J. van der,Rall, Gerhardus J. H.,Roux, David G.
, p. 2684 - 2691 (2007/10/02)
Photolysis of pterocarpans in methanol or acetic acid provides the first general and also direct method of access to 4-functionalized 2'-hydroxy-3,4-trans-isoflavans by C-ring fission and solvolysis.Spontaneous recyclization to the pterocarpan is governed
