462629-40-9Relevant academic research and scientific papers
Alkenyl tricarbonyl derivatives of α-amino acids as trielectrophiles. Formation of heterocyclic-substituted products
Wasserman, Harry H,Long, Yun Oliver,Zhang, Rui,Parr, Jonathan
, p. 3351 - 3353 (2002)
Alkenyl tricarbonyl esters have been prepared by reaction of mono aldehydes of dibasic amino acids with tricarbonyl esters. These systems undergo reaction with diamines and other dinucleophiles by a combination of Michael addition and nucleophilic attack at the electrophilic central carbonyl to form pyrrole derivatives. These monoaldehydes may also be used to incorporate imidazole and furan residues into the amino acid starting materials.
Formation of heterocyclic derivatives of α-amino acids using vicinal tricarbonyl methodology
Wasserman, Harry H.,Long, Yun Oliver,Zhang, Rui,Parr, Jonathan
, p. 393 - 403 (2007/10/03)
Monoaldehydes derived from diesters of N-protected aspartic and glutamic acids have been reacted with precursors of vicinal tricarbonyl esters to form electrophilic products. These substances were converted to heterocyclic derivatives of the amino acids.
