46276-89-5Relevant academic research and scientific papers
Highly potent inhibitors of the Grb2-SH2 domain
Schoepfer, Joseph,Fretz, Heinz,Gay, Brigitte,Furet, Pascal,Garcia-Echeverria, Carlos,End, Nicole,Caravatti, Giorgio
, p. 221 - 226 (2007/10/03)
Highly potent inhibitors of the Grb2-SH2 domain have been synthesized. They share the common sequence: Ac-Pmp-Ac6c-Asn-NH-(3-indolyl-propyl). Different substituents at the 3-indolyl-propylamine C-terminal group were explored to further improve the activity. This is the first example of inhibitors of SH2 domains with sub-nanomolar affinity reported to date.
